Just thought I would like to send encouragement to all of you worried about taking mtx. I was diagnosed in Jan 2012 and was started on mtx .Today I have been told I am in remission after tapering off the drug since February. I am aware that it could return but I am crossing my fingers while I can. I was very wary about this drug but apart from a couple of hiccups when the dose was raised , it has been good. Good luck to those about to start.