For the past 6-7 weeks I have been getting headaches, loss of concentration, sweats, tight chest,irritating cough and an awful colour to my skin. Well I had a problem with pred and had to come off it, the main side effects of that subsided as I came off it (never again to go on it!) but all the above continued, and I think I started to age as well. So I had a think about what other changes had happened easy Sulfasalazine! I had never managed to increase the dose up to the required 2 twice a day because of the headaches, was the low dose contributing? I stopped taking them on Saturday last and slowly but surely I am feeling much better and the above are improving--now I don't see my rheumy nurse til next week, so I won't tell her til then about my little experiment. She was thinking of trying me with Embral, but do you know what? I can do without the side effects of all this stuff and just stick to the MTX and NSAIDS, unless anyone can tell me there are no side effects from it!!