Another monoclonal antibody treatment on the way?

[gustavwind]

AstraZeneca has just announced "positive results" from its SUPERNOVA Phase III trial on sipavibart (AZD3152), the updated version of Evusheld:

astrazeneca.com/media-centr...

The press release states that they are in touch with regulatory authorities on developing a pathway for approval, so perhaps it will become available some time in the next few months (perhaps sooner?).

On a related note, has anyone received Pemgarda (that was announced in late March)? My nephrologist - at a prominent major metropolitan medical center with a large transplant center - said that the treatment is currently not available there, due to lack of demand. Has the word not gotten out yet? (For those who are interested, I contacted Invivyd, and doses are indeed available to providers through approved distributors.)

[Bassetmommer]

I take a biologic that is a monoclonal antibody. Anyone on Remicade already has this protection.

[Transplant2018]

I'm also having trouble getting Pemgarda.

[Ar2D2]

My doctor wanted me to participate in this study, but there was only a 50% chance I would be getting the actual drug and they required a bunch of morning appts which wasn’t conducive to working full time so I didn’t do it. Hope this becomes availble soon! I had evushield shot when that was effective and it did give me some peace of mind.

I Haven’t heard anywhere near me that has the pemgarda available…

[Bouvierlover2 in reply to Ar2D2]

It is more readily available now. Check the Invivyd website ..,they now have a locator to receive it. It is getting better. I was in the trial. Very slow roll out 😬

[ShyeLoverDoctor]

I can’t get pemgarda yet either however it does have a 0.6% chance of life threatening anaphylaxis, black box warning, so I’m not so sure I really want it.

[Oceansideup]

Pemgarda also has to be given by IV (from what I read).

Looks like the sipavibart is an injection, if that makes any difference for people…

[GardnerADK]

Thanks for sharing this news about another drug to help whole organ transplant recepients and others too. I did my own research online about Pemgarda and the study was not large, like around 686 people and only 33 from the entire study were whole organ transplant recepients. That gives me alot of concern and my spouse with the kidney transplant will not be looking into taking this new drug via infusion every 3 months. I realize it is a personal choice.

[Bouvierlover2 in reply to GardnerADK]

I have received 3 infusions and no issues with my labs at all! Kidney transplant 13 years out! Creatinine was not affected at all and my transplant doctor was fine with it!

[DexterLab]

I got a big yawn when I was at the transplant center when I mentioned Pemgarda. Not the same as when Evusheld came out. I guess I will wait.

[Transplant2018]

I am anxious to get Pemgarda because I generated no antibodies to my many Covid vaccines. Gratefully my transplant center is now trying to order it for me. But what about all the other transplant patients? I don't understand why centers don't communicate with patients about these mAbs.

[Bouvierlover2]

I was in the study and received the drug. Had two doses and absolutely no reaction. Invivd now had a rather rough Pemgarda locator. Medicare does pay for it!!

Also check with your local infusion Centers! Most just need a RX from your physician.

Here is a locator!

locator.infusioncenter.org/