Immunogenicity of COVID-19 Vaccine in Organ Transplant Recipients

[Kidney2014]

Immunogenicity of a Single Dose of SARS-CoV-2 Messenger RNA Vaccine in Solid Organ Transplant Recipients

jamanetwork.com/journals/ja...

“In this study of immunogenicity of the first dose of the mRNA SARS-CoV-2 vaccine among solid organ transplant recipients, the majority of participants did not mount appreciable antispike antibody responses.”

“These findings of poor antispike antibody responses in organ transplant recipients after the first dose of mRNA vaccines suggest that such patients may remain at higher early risk for COVID-19 despite vaccination. Deeper immunophenotyping of transplant recipients after vaccination, including characterization of memory B-cell and T-cell responses, will be important in determining vaccination strategies as well as immunologic responses after the second dose.”

[desperateboy]

It is ok. It is well known in all vaccines from past to present. Vaccines are not as much as effective for us compared to healthy people. After the second dose, again nothing will change. It won't last long, I will not talk about t-cell stories in our situation.

Let's just be 🙈🙉🙊

[pops81 in reply to desperateboy]

Agree, for example I've never gotten the flu shot to prevent the flu. I took the flu vaccine to minimize its impact on me, my general health (and the kidney), and minimize its spread. Don't know if that's following the science but its worked for me and this summer that will be 40 years. I will continue to be safely distant from people out of my bubble, wear a mask when needed and yes I got the J&J vaccine almost two weeks ago but will remain cautious as this is all figured and we begin to go in a forward direction. Stay healthy and mask up.

[LisaSnow in reply to desperateboy]

I got a high tier of SARS-CoV-2 S antibody one month after my second dose. I think you will be fine too.

[Kidney2014 in reply to LisaSnow]

That’s great you got a high tier count of antibodies! I hope we get more data and positive news for those on immunosuppressants.

Unfortunately for me, I did not develop a strong immune response after my second dose. I had the anti-spike Elisa quantitative test done at my transplant hospital, and the count was low. But according to my neph, some patients did not develop any antibodies. So some protection is better than none!