since my HU was increased 3 times last year my ESR has been going up after every increase and wbc dropping after each increase.
What can I take instead of Hu which doesn’t increase ESR and reduce WBC ?
I’ve noticed that with. ESR going up so did my platelets go up. Then the WBC drops after increasing Hu
I’m in a lot of pain . Sure I need HU reduced and anti inflammatory medication
Cytoreductive agents like HU will generally reduce all three types of blood cells to varying degrees. The other first-line treatment for ET is Pegasys. While you might respond better to PEG than HU, there is currently a PEG shortage so you may not be able to switch. PEG also lowers WBCs. The other option for treating ET is anagrelide, which more specifically targets platelets; however, anagrelide is harder to tolerate for many people.
You have a complex case with overlapping conditions that likely impact each other. The rising ESR might be related to HU somehow triggering inflammation but could just as easily be due to other changes in your body. This is going to be difficult to sort out. We discussed consulting an Integrative or Functional medicine doctor previously. Suggest a fresh perspective on your case could be very helpful.
I have no idea how to find an intergrative Dr here in uk though .
Plus if I found one it would have to be near to me
Integrative and Functional Medicine are two similar disciplines. Some doctors practice both.
Functional medicine doctors can be found on this site. ifm.org/find-a-practitioner/
Integrative medicine doctors can be found with a Google search. Click on the map for a larger view. google.com/search?q=integra...
What is ESR?
labtestsonline.org.uk/tests...
Why have you sent me that link?
It was really to Jamesxyz to answer their question ‘what is. ESR’. The labtestsonline site can be useful for understanding various tests.
Inflammation marker
Low WBC count
Besremi progress
I’m really scared... high wbc count and elevated platelet count...
High white blood cells 
Hydroxyurea, PV and itching...
