Interferon with PV JAK2/DNMT3A

[Fivecatsandcounting]

I'm waiting to see my latest genetic results of JAK2 ab and also if any changes to DNMT3A. I've been on Interferon (90 and then 135mcg) since beg September last year and I wonder if DNMT3A may be causing interferon resistance. I am curious to see if it's just holding the bloods and mutations where they are (rather than improving as would be expected from Interferon) or if the mutations are worsening. Would be interested to hear if anyone else has experience of this? ❣️ Next step, see if higher dose is having any effect by end July, have another venesection if needed (I have PV with high platelets too) and maybe add hydroxy to the mix for a while. ❣️ Otherwise change of drug altogether. Under Guys.

[EPguy]

Combo therapy could be a good option.

Here are a couple old posts on the subject. Indications are DNMT3A are a negative for responses. But as with every study, these averages don't predict any one pt's result. And there may be other studies with different findings.

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This study looked at DNMT3A closely.

healthunlocked.com/mpnvoice...

"DNMT3A is most associated with non-CHR (Complete Hem Response)"

"TET2, DNMT3A, or ASXL1 associate with older age and major thrombosis and esp prior stroke (odds ratio 5.2) this is very strong correlation when both age and these mutations are present."

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healthunlocked.com/mpnvoice...

"Concomitant TET2 or DNMT3A mutations are associated with molecular resistance to interferon"