I have been taking Pegasys for little less than a year at a fairly low dose. I had some warning signs of migraine (painful to move head) a few times, which I attributed to dehydration, but then had a vicious migraine for 2 days within 7 days of a Pegasys injection (45 mcg). I had never had a migraine before this. I lengthened the time between shots and had no subsequent problems. A few months later my hematologist wanted me to increase the dose to reduce platelet level, which was in the 700s. I stupidly dosed at a much higher level (about 80 mcg) and within 5 days had a bad migraine for 7 days, which is still continuing although I am recovering.
My migraine was severe and included sore hips and toe joints. Since I have suffered from psoriasis in the past, I believe I am at risk of autoimmune reaction to Pegasys. I know some of you have stopped Pegasys because of autoimmune risk, and I am wondering if anyone has experience they would be willing to share. All input is appreciated. Thanks so much.