tasquinimod in myelofibrosis (MF)

[Manouche]

 »The data showed that treatment with this drug results in normal blood counts, reduction of fibrosis in the bone marrow and normalization of spleen size in this mouse model. That suggests that tasquinimod can act as a disease modifying agent in MF »

« The now planned study will investigate tasquinimod given as monotherapy to patients with myelofibrosis who have previously been treated with a JAK inhibitor or who are ineligible for JAK inhibitor treatment. The trial will be conducted at sites in the Netherlands and in Germany, with HOVON as the sponsor of the trial ».

oncode.nl/news/oncode-insti...

[champ30]

Interesting for us with MF.

[beetle]

Lucky mice! I hope it is as successful in humans. I dream of normal blood results and a normal spleen! There are so many exciting bits of research happening which is why even at my advanced stage I never give up hope

Jan

[Meatloaf9]

Thank you for posting this info. The trials can't happen soon enough. Fingers crossed.

[Pte82 in reply to Meatloaf9]

Looks like in May 2022 FDA granted it orphan drug designation in myelofibrosis.

activebiotech.com/en/projec....

[Bainbridge]

thanks for sharing since my husband has high risk MF and this would be a game changer for sure !

[Pte82 in reply to Bainbridge]

I hope so, neither of my wife's oncologiasts mentioned tasquinimod even though one was in a hospital in touch with clinical trials and one would think in May of 2022 they would be aware. She had late stage MF and passed in August 2022.

[Bainbridge in reply to Pte82]

Sorry meant your wife typo

[Bainbridge]

So sorry to hear about your mom. I also worry about my husband who is 74 yrs old and this year progressed to high risk MF and started on RUX/Jakifi, they want him to consider a SCT but his siblings are only half match and the donor banks have no full match. It’s a difficult decision so I am always looking for new clinical trials. I did share this link with the MNP doctor we see in the USA the other day and she did not hear about it but to keep her posted on this

So we are continuing with the current therapy which makes him very anemic that he requires blood transfusions but we may be starting a clinical trial for DISC 0974-102 which will help his anemia but not stop the disease

So the good news is that there are glimmers of hope for new drugs and just pray they work and get released sooner than later

Thanks again for sharing

[Pte82 in reply to Bainbridge]

My wife had a picc line installed at the hospital to offer relief from all the transfusions and blood work. She was prescribed pacritinib (Vonjo) when it was approved in early 2022. Her MF advanced to leukemia and all treatment was withdrawn. Be mindful of diet, avoid sugar and pray.

[Bainbridge in reply to Pte82]

Thanks for this info it is very helpful. My husband has MF with three mutations JAK2, e2h2 and ASXL1 which I understand is the one that can progress to leukemia. He was diagnosed in 2020 and did fine on HU then this past year in March got very fatigue, pain from the spleen he was miserable and progressed to high risk . The jakifi is helping but makes him anemic so he has had to have blood transfusion it’s a difficult decision since SCT for half match is not ideal plus what one has to go thru is very difficult on one’s body at his age and also not many people his age has SCT

So once the MF goes to leukemia they withdraw the treatment? And I try to have a diet of anti inflammatory and no processed or fried food. He does like ice cream but should probably cut that out. One does not know if and when it will progress to leukemia but the doctors at the time of diagnosis gave him 86 months which is like 7 years

There is also another clinical trial NCT05423691 which seems promising and we did speak with the Dr at MD Anderson. She said to keep in contact since they are just recruiting and to wait

This forum has been very useful and helpful