aspirin question?

[shiela23]

who’s taking aspirin only for treatment ET … how much dosage for 1 day?

[hunter5582]

I took a standard 81mg/day dose for many years with ET. Note that people who are more symptomatic sometimes use 81mg/2x-day.

As I aged (age>60) I found that I reacted much more strongly to aspirin with excessive bleeding/bruising, particularly if my platelets were near/over 800K. I discontinued aspirin for a while but had to resume due to microvascular symptoms. I did use 40.5mg/day (1/2 chewable tab) for a while, with resolved the symptoms.

Now that my thrombocytosis is so well controlled on Besremi, I have found that I tolerate the 81mg/day dose with no excessive bleeding/bruising. I have elected to use the Vazalore formulation of aspirin as it is supposed to be easier on the stomach. Important because I have GERD.

Hope that helps. m

[shiela23 in reply to hunter5582]

what platelet count are you now?

[hunter5582 in reply to shiela23]

My platelets are cycling anywhere from 294 to 395 lately. Historically, I usually cycled 550 - 750. I achieved normal platelet levels within 8 weeks of starting the lowest dose of Pegasys, 45mcg/week. I later switched to Besremi. For me, the interferons have done a much better job controlling the blood counts and have been much easier to tolerate than hydroxyurea.

Note that my ET has progressed into PV, so I need to control both erythrocytosis and thrombocytosis. In fact, with PV, erythrocytosis is more important to control than thrombocytosis. There is no direct link between the level of thrombocytosis and risk of thrombosis. While we pay attention to the platelet levels, it is the erythrocytosis that matters the most.

All the best.

[hunter5582 in reply to shiela23]

Cycling 294 to 395 recently. Trending on the lower side of that lately.

[Amethist]

Hi, I have ET and only take aspirin. After a great deal of research and speaking with an MPN expert who agreed with me, I just take ½ a regular aspirin every 3rd day. I found daily aspirin resulted in excess bruising. I tried stomach friendly - coated mini aspirin and it did nothing. Since diagnosis I’ve always had high platelets (1200-1600). Other than occasional tingling in my toes, I have no other symptoms. The aspirin completely eradicates the tingling for 3 days and I just get on with enjoying life .

I have also made my diet more healthy and I do take regular vitamin and mineral supplements.

[Sprat19]

if you are in the UK our tablet size is different. I was on 75mg for years. Now also on peg but that’s due to age

[Staroftheday]

hi lovely I got diagnosed in June this yr I take one aspirin 75mg a day , but my last conversation with the doctor he was talking abt an injection the lowest form I go back the hospital in October x

[ritaandscooter1]

Hi, I have had PV-Jak2 for over 20 years and started on one low dose aspirin a day and then turned 60 and MPN specialist recommended 2 aspirin a day which I've been taking for awhile. I couldn't tolerate PEG and refuse to go on HU because of skin cancer risk. Platelets usually around 1000 and WBC's around 20. I am so far doing well on this regimen. Kerry