Can any one give a simple summery of this article please

[Mostew]

ncbi.nlm.nih.gov/pmc/articl...

It’s regarding effect of mushrooms on platelets .

To complicated for me!!!

[JediReject]

Hi Carolyn, , haha no wonder you asked this. However I skipped to the conclusion on P28 which states " The blood coagulation parameters were NOT significantly altered by any mushroom extract" .

Case closed I guess. But still worth foraging for those 'magic' mushrooms which help you forget all about your MPN and other ailments.

Regards - Chris

[Mostew in reply to JediReject]

Thanks ChrisGood short summery ...

You remind me or my 'mispent' youth!!!

Carolyn

[EPguy]

I checked it out. Nothing clearly actionable but some items maybe of interest:

It studied hot water extract, I think because you might get it this way from flavorings in cooking. This would differ from eating the shrooms.

<<The hot water extracts were specifically utilized since they more closely reflect the situation of mushroom consumption compared to organic-solvent extracts>> An example of organic solvent is paint thinner.

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<<In all four cases, (4 specific shrooms) the (anti-aggregation activity) responses exceeded what was induced by 140 µmol/L of ASA(aspirin) >>

<<Treatment of human plasma with mushroom extracts did not result in altered clotting.>>

I had not thought about aggregation vs coagulation. Best I can tell, agg is where the PLT clumps together, while coag is where they plug up something. I'm sure this is over simplified. But the report shows that some shrooms can be quite good to reduce agg, and this seems to be a good thing.

--

Not affecting coag is a good thing and shrooms may be better than aspirin: <<For example, it has been established that ASA (aspirin) administration can lead to ... in an increased risk of bleeding. This has also been observed in the present study after in vitro treatment with 140 µmol/L of ASA. Importantly, none of the studied hot water extracts (of mushrooms) affected coagulation parameters, which provides a potential additional advantage of their use as a part of prophylaxis of CVD.>>

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ROS is a recent focus of MPN research, (see NAC supplement) so some shrooms may be good here: <<As shown previously, the hot water extracts of P. eryngii ...increased antioxidative activities in isolated human platelets by preventing ROS formation and lipid peroxidation>>

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In the Voice post:

healthunlocked.com/mpnvoice...

lindabomba notes Lion's Mane vs fatigue. This is "Hericium erinaceus" which was included in this study. Not much detail on it here however.

[Mostew in reply to EPguy]

Thanks for thoughts . Trouble with replacing aspirin with something else is getting correct dose. No functional practitioner I’ve asked has recommended not taking aspirin …

[EPguy in reply to Mostew]

I agree, this report has few specifics. I was just sort of translating and interpreting it to help with the title post. It is also only in vitro ("test tube"). This is only the 1st of three main steps, next would be in vivo (in a mouse for example) Finally human clinical trials. All this is very complex, so we see only the most promising and clear results progress to these stages.

This report does not meet the clear results hurdle in my opinion. My thought is the ones we all can understand are the ones that deserve the most attention.

[Mostew in reply to EPguy]

I agree .

[lynnieb]

I was interested to read this, but unfortunately, it might as well have been written in Swahilli. Not a clue what it was saying. If anyone COULD translate, I too would be interested

[EPguy in reply to lynnieb]

I did provide some summary. But as you see in my reply above, this report is not easily digested. A main point was comparing certain mushrooms to aspirin. Some possible advantages were noted for shrooms. But as Mostew says above, changing well established practice based on this uncertain report is not a good idea.

[Vtr1000 in reply to EPguy]

Hi EPguy, just like to say thank you for all your input in deciphering the technical info into the average persons understanding. Thank you.