MF and Pacritinib

[EPguy]

I've been looking at the Twitter feeds for ASH 2021 and others.

ashpublications.org/ashclin...

In this study Pactritinib (Pac) is impressive. See chart here (from the twitter list)

twitter.com/MPN_Hub/status/...

However between BAT (mostly Rux) and two dosing levels of Pac <<Overall survival was not significantly different between the three groups>>

But switching to Pac seems beneficial:

<<In the BAT cohort, the overall mortality rate was lower among those who crossed over to receive pacritinib>>

and <<Clinical improvement in hemoglobin and reduction in transfusion requirements were also more frequent in patients who received pacritinib, particularly with twice-daily dosing>>

[Dodders]

I was on a Pacritinib trial at the Christie Manchester under prof Somerville 3 years ago. I did this after Rux ceased to be effective for me. I had post PV MF. There were some beneficial effects, particularly with reducing night sweats. Overall though I recall that it did not make any significant difference to my overall situation. I came off the trial before completing it when the opportunity to have SCT arose. I have sometimes wondered whether Pacritinib has been approved.

[EPguy in reply to Dodders]

Thanks for the info from a real trial patient. The results were supposedly better but in the chart here that still leaves 75% non-responders and minimal survival benefit. Like so much in our journey, no easy answers.

I see your SCT is going well, that is fabulous news. As we know so far that's the only recognized potential curative.