Anyone had problems with elevated Liver function... - MPN Voice

MPN Voice

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Anyone had problems with elevated Liver function tests while taking Hydroxycarbamide…. Would be pleased to get some information ….

Hydranga18 profile image
10 Replies

ET mpl on Hydroxycarbamide 500 mgms daily …

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Hydranga18 profile image
Hydranga18
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10 Replies
PhilReade profile image
PhilReade

Hi mine are always up my bilirubin and ALP and ALT all raised but Proffessor I’m under doesn’t seem worried

Hydranga18 profile image
Hydranga18 in reply toPhilReade

Thank you for that information … 🙏🏽

tracey13 profile image
tracey13 in reply toPhilReade

My husband's liver function bloods were always high on hydroxy. He was sent to a liver specialist he said he had NASH liver non alcoholic related he did change his diet and that brought the numbers down a bit but it does say medication can cause LFTs to be high .

X

Hydranga18 profile image
Hydranga18 in reply totracey13

Thank you all who replied on subject of Liver Function tests… Hope you are all keeping well ,

hunter5582 profile image
hunter5582

Hepatoxicity is one of the known toxicities associated with hydroxyurea. online.epocrates.com/drugs/...

drugs.com/monograph/hydroxy...

Monitoring liver function is one of the requirements for use of HU. Signs of significant liver impairment may require a change in your treatment plan. Fortunately there are other options should you not be able to tolerate HU.

Hydranga18 profile image
Hydranga18 in reply tohunter5582

Thank you Hunter, I was so worried … it is such a consolation to have such a knowledgeable person like yourself ,on this forum … 🙏🏽

Virginia91 profile image
Virginia91

Hi, I have fluctuating values in my blood tests concerning the liver. Yesterday my haematologist said she was going to consult with someone from the gastro.dept. She wondered if it could be caused by a gallstone.The values were also a bit high before I began with HU. I don't drink.

However they have been relatively high then the next month they were fairly ok.

sláinte

Hydranga18 profile image
Hydranga18 in reply toVirginia91

Thank you Virginia 91…

tracey13 profile image
tracey13 in reply toVirginia91

Funny you should mention gallstones as my husband had emergency surgery last year to get his gallbladder removed .He went in hospital in absolutely agony they ended up sending him home 6 days later he was back in with sepsis and he had emergency surgery.

Virginia91 profile image
Virginia91

Hi, it's hard to know sometimes what is causing what. I hope your husband recovers soon. It sounds like it was an ordeal. All the best.

🙂

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