Question for those taking PEG Interferon - MPN Voice

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Question for those taking PEG Interferon

Tylerdog1 profile image
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After taking 135mcg of PEG Interferon since January 2020 (just over a year) my Haematocrit level is still high at 48 (all other counts are now OK - Platelets down from over 1000 to 300)

My consultant wants to increase dosage to 180mcg for next two months

Is anyone else taking this sort of dose .... I do tolerate it well, but a little concerned that it does not appear to be working for me

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Tylerdog1
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MPNBlog profile image
MPNBlog

My understanding is that such high doses are only used for hepatitis. And that PEG may not fully control your Hct - you'll need to still have some venesections. So if that's the reason for the increase in dose, and your other counts are going well, I personally would say no (and get a venesection so your Hct is below 45). It's good news about your platelets (which PEG mostly affects). Higher PEG doses could result in your platelets getting too low. After a year on 135mcg I'd be considering lowering the dose. I suggest you read the work of J.J. Kiladjian from Paris who has done a lot of work on PEG. (I'm on 45 ug every 3 weeks.) I hope that gives some more information for you to consider. Best wishes.

Grace71 profile image
Grace71

Hi, I'm on 180mcg every week with a top up of 90mcg every other week - has worked very well after platelets went high during change from previous interferon over to peg version. I'm happy with the lower platelets and suits me injecting (not for everyone - I know!) All other levels are also within range and kidney/liver function good too. I'm ET JAK2, incase that helps with your thinking around using this drug - the results on my platelets are good and improving each three months - so I may end up with a reduction, if levels stay good.Good luck with your decision making about medication.

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