Therapeutic Cancer Vaccination With a Peptide Derived From the Calreticulin Exon 9 Mutations Induces Strong Cellular Immune Responses

[Manouche]

« Conclusion: Therapeutic cancer vaccination with peptide vaccines derived from mutant CALR with montanide as an adjuvant, is safe and tolerable. The vaccines did not induce any clinical responses. However, the majority of patients displayed a marked T-cell response to the vaccine upon completion of the trial. This suggests that vaccines directed against mutant CALR may be used with other cancer therapeutic modalities to enhance the anti-tumor immune response. »

frontiersin.org/articles/10...

[Aneliv9]

I read it to,but i couldn't understand the importance of this vaccine since it didn't have a clinical response... Something about immune boosting but I can't understand if this is important enough!!!

[socrates_8]

Hey Manouche...

Have heard of similar trials w/ CALR sometime ago... Nothing conclusive as yet, as I understand...

However, I have only quickly scanned through this Paper thus far, and it has piqued interest...

I shall have a more thorough read in due course...

Thanks buddy...

Steve

[MPort]

Does this imply that this new cancer vaccine will work like the Pfizer vaccine. It won't deliver a tiny dose of 'cancer' as in principal of measles vaccine but stimulate these T cells to work against the tumour. But CalR is a mutant gene. We have been assured that the new technology in the Pfizer type vaccines won't change DNA so how can this work. I would like to understand the logic of it.

[Manouche in reply to MPort]

“How do cancer treatment vaccines work?

Antigens, found on the surface of cells, are substances the body thinks are harmful. The immune system attacks the antigens and, in most cases, gets rid of them. This leaves the immune system with a "memory" that helps it fight those antigens in the future.

Cancer treatment vaccines boost the immune system's ability to find and destroy antigens. Often, cancer cells have certain molecules called cancer-specific antigens on their surface that healthy cells do not have. When a vaccine gives these molecules to a person, the molecules act as antigens. They tell the immune system to find and destroy cancer cells that have these molecules on their surface.”

cancer.net/navigating-cance...

[MPort in reply to Manouche]

Thank you. That is very helpful. Now am I right in thinking this new technology won't work for PV or ET? Our red blood cells and platelets are normal but there is just too many of them? Or am I still on the wrong track?

[Manouche in reply to MPort]

Hi MPort,

Theorically it could work. Our BC and plts are not fully functional and normal.

medscape.com/answers/205114...

[Bridie123]

Does this help us? I have the Calr mutation