Reconstructing the Lineage Histories and Differentiation Trajectories of Individual Cancer Cells in Myeloproliferative Neoplasms

[Manouche]

« This suggests that peripheral blood monitoring may not accurately assess JAK2 mutant allele burden, particularly in megakaryocyte-erythroid lineage cells and HSCs. Finally, the JAK2-V617F mutation has been shown to have cell-intrinsic effects not only in leukocytes but also in erythroid cells and platelets. Our observation of high JAK2-V617F allele fractions in megakaryocyte-erythroid lineage cells in individuals with low peripheral blood JAK2-V617F mutational burden may help explain the development of thrombosis in these people. »

cell.com/cell-stem-cell/ful...

[BeHealthy1986]

This is interesting. My doctor didn’t find any mutation in my peripheral blood, then he suggested a BMB to run the same genetic test since he said bone marrow aspiration is more sensitive to find myeloid mutation. In my case, I’m still negative. Waiting for the next appointment to learn more details.

[Tess74]

interesting, i'm jak2 neg pv but a bmb found dysplasia in both megakaryocyte-erythroid lineage cells, i wonder if theres a connection!?!....I've not read the link yet but will do later, thanks x

[socrates_8]

Hey Manouche...

Just downloaded the full article they refer to earlier today...

What I find really interesting is that this has been quite an obvious story now for quite sometime, in my view...

But really does make for a good read all the same...

Thanks buddy...

Steve

PS. PDF full Paper Link below:

cell.com/action/showPdf?pii...