Hello. My issue began in August 2020 with a persistent itch to my upper right arm which when scratched became worse. The itching spread to my back and legs and became intolerable. Consulting my GP I discovered that I had had a high platelet count since 2017. This had never bothered me until the itching began. To be brief blood tests followed resulting in me being referred to Haematology. I was diagnosed with ET and prescribed Hydroxycarbamide 500 mg one tabled per day which I started mid December 2020 just a week ago. My understanding was that this would solve the itching by reducing the platelet count the high count being its source due to the release of excessive histamines and other chemicals into the blood. I had previously been prescribed Fexofenadine antihistamine by my GP for the itching and asked the haematologist if I could take this alongside the Hydroxycarbamide. This was agreed and I have taken but unfortunately so far the itching is if anything worse. I wondered if anyone might have had a similar experience and found an answer?