Another possible MF ‘cure’ but very early stage....

[Paul123456]

apnews.com/Business%20Wire/...

“This clinical trial will evaluate the ability of AVID200 to achieve the disease-modifying outcomes of reversing bone marrow fibrosis and restoring normal hematopoiesis. Preclinical data demonstrate that selective neutralization of TGF-beta 1 & 3 by AVID200 results in both of these critical outcomes. We believe that AVID200 has the potential to become the first disease-modifying treatment for MF,” commented Dr. Ronald Hoffman, founder of the MPN-RC and Director of the Myeloproliferative Disorders Research Program at the Icahn School of Medicine at Mount Sinai.

[Paul123456]

Another release from MPN Foundation re AVID

mpnresearchfoundation.org/C...

[huisiebydiesee]

Thanks, Paul. Very encouraging news! Please keep posting any updates in this. I would be very willing to join trials!

Shirley

[Raminus]

Is it possible to join a trial here in Australia?

[welshhuw]

Thank you Paul for sharing this information..... always encouraging to hear of potential new treatments entering clinical trials. Please keep posting !

[Rachelthepotter]

Thanks for this, Paul. Very encouraging.

One thing that puzzles me is why drug treatments for MF seem to be the research focus when MF is such a rare condition even within the MPN group. As we saw at the Oxford forum : only half a dozen people in the MF breakout group.

I’m not complaining, because MF is what I have, but I don’t get the economics of it.

Any thoughts?

Rachel

[ccsial in reply to Rachelthepotter]

Maybe because MF has the worst outcome.

[DJW1 in reply to Rachelthepotter]

I think there are a number of reasons; although rare, mf affects 30,000 people in the U.S. alone. That is a lot of people. Also many mpn patients with ET and PV do progress to MF. Finally, the fatality rate for patients with mf is much more grim than those with other mpns; that alone is a good reason for the research. By the way, I was in attendance at the MPN conference at the Mayo clinic, and there were a lot of mf patients present. Finally, Leukemia kills about 350,000 a year world wide, and mf develops into a very serious form of leukemia about 20-25% of the time, so again, morbidity is a huge reason for research. MPNS are rare overall, but not as rare as a lot of us think, there has been a lot of mis-diagnosis of the disease historically. Now that awareness is increasing, so are rates.

[Rachelthepotter in reply to DJW1]

Thank you for your response: those numbers make sense. As I said, MF is what I have, and ruxolitnib has helped a lot, but it’s a pity that its main side effect is anaemia leading to fatigue.

[Paul123456]

This is video link to Presentation re new treatments, go to 44th minute re AVID200.

youtu.be/lbd7kvKIAy0(Not working as expected?)

And a link to all the recent Presentations (I have posted this before)

mpninfo.org/conferences/201...

[Aneliv9]

If this drug works , it means that is like cure? Will prolong life expectancy? I cant understand exactly!