My ‘crossover’ MPN has transformed to Myelofibrosis ( confirmed by BMB) and my new consultant has decided that the only medication is Ruxolitinib. Can anyone reassure me as to its efficacy, and if they have suffered side effects..... it all sounds quite toxic. My HB has also plunged to 60, and I will be having regular blood transfusions. I am quite depressed as it appears that this new diagnosis is life limiting. Any comments?