Hi all, I've been wanting to reply to all the wonderful folks that posted on my Chemicals/ET post. A reaction to the Hydrea I have been taking for 3 weeks for my JAK2 ET put a spanner in the works. My legs erupted in large red painful hot lumps. Walking was difficult. I was diagnosed with Erythema Nodosum and was told to stop! taking Hydrea. I am seeing the oncologist next week re new plan of action. Anyone else experienced this Hydrea side effect? I wish you all well. Yvette from South Africa.