FSpeckled Pattern1:80
- Dense Fine Speckled pattern is noted. This pattern suggests
- the
- presence of DFS70 antibody which has a low prevalence in
- systemic
- autoimmune rheumatic diseases.
FNOTE:Comment
- A positive ANA result may occur in healthy individuals (low
- titer) or be associated with a variety of diseases. See
- interpretation chart which is not all inclusive:
- .
- Pattern Antigen Detected Suggested Disease Association
- ----------- ---------------- -----------------------------
- Homogeneous DNA(ds,ss), SLE - High titers
- Nucleosomes,
- Histones Drug-induced SLE
- ----------- ---------------- -----------------------------
- Speckled Sm, RNP, SCL-70, SLE,MCTD,PSS (diffuse form),
- SS-A/SS-B Sjogrens
- ----------- ---------------- -----------------------------
- Nucleolar SCL-70, PM-1/SCL High titers Scleroderma,
- PM/DM
- ----------- ---------------- -----------------------------
- Centromere Centromere PSS (limited form) w/Crest
- syndrome variable
- ----------- ---------------- -----------------------------
- Nuclear Dot Sp100,p80-coilin Primary Biliary Cirrhosis
- ----------- ---------------- -----------------------------
- Nuclear GP210, Primary Biliary Cirrhosis
- Membrane lamin A,B,C
- ----------- ---------------- -----------------------------