LUpus Patients Understanding and Support

Can someone help me understand these test results?

FSpeckled Pattern1:80

- Dense Fine Speckled pattern is noted. This pattern suggests

- the

- presence of DFS70 antibody which has a low prevalence in

- systemic

- autoimmune rheumatic diseases.


- A positive ANA result may occur in healthy individuals (low

- titer) or be associated with a variety of diseases. See

- interpretation chart which is not all inclusive:

- .

- Pattern Antigen Detected Suggested Disease Association

- ----------- ---------------- -----------------------------

- Homogeneous DNA(ds,ss), SLE - High titers

- Nucleosomes,

- Histones Drug-induced SLE

- ----------- ---------------- -----------------------------

- Speckled Sm, RNP, SCL-70, SLE,MCTD,PSS (diffuse form),

- SS-A/SS-B Sjogrens

- ----------- ---------------- -----------------------------

- Nucleolar SCL-70, PM-1/SCL High titers Scleroderma,


- ----------- ---------------- -----------------------------

- Centromere Centromere PSS (limited form) w/Crest

- syndrome variable

- ----------- ---------------- -----------------------------

- Nuclear Dot Sp100,p80-coilin Primary Biliary Cirrhosis

- ----------- ---------------- -----------------------------

- Nuclear GP210, Primary Biliary Cirrhosis

- Membrane lamin A,B,C

- ----------- ---------------- -----------------------------

1 Reply

The ANA test is just one blood test to help make a diagnosis. As you can see, it notes that a positive ANA is seen in "healthy people."

If you are concerned about a diagnosis of systemic lupus erythematosus, your first priority is to get to see a lupus specialist, as not all rheumatologists are expert in SLE. I don't know where you live so I cannot comment.

I have written a post about ANA tests here:

but there is also information on the LuPUS Message Board, where you will need to create an account.

You cannot make a diagnosis of SLE based on ANA tests. Additionally,even if the ANA is negative, this doesn't rule out SLE because there is a condition called: sero-negative SLE.

This paper helps to understand how to make a diagnosis, based on the patient's symptoms. It is written by Dr Graham RV Hughes, who is an internationally renown lupus specialist:

With good wishes,



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