I have been on and off prednisone for the last 8 years. It is taking more and more prednisone to hold my count to 20,000. I am lucky, I have never had a bleed. (although, there was a bleed blood behind my retina eye..sometimes the doctor says that is not from itp..then they say it could be. Coming off the prednisone, I really have withdrawal..with aching and exhaustion. (I also have an undefined tissue disease.) The doctor is suggestion rituxan, but I am not sure that I want to try this drug. I sometimes wonder if I should treat at all. I have dropped to a count of 8,000 at one time. I am a very active person. Does anyone have any comments, experience with rituxan, and also not treating at all. All information will be appreciated.