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I have APS, Hughes Syndrome

ltsmagic profile image
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I have APS, and every time I take the test for Covid, it comes up positive. I have so many antibodies in my system because of Lupus, I wonder if I am positive because of my white blood cells? I have already done the Plaxovid regimen. I was feeling so much better, but then a week later I woke up with a sore throat. Should I go back to the Dr. an have them test me again?

Thank you!

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ltsmagic profile image
ltsmagic
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lupus-support1 profile image
lupus-support1Administrator

When in doubt, see your doctor.

Antibodies can't cause "covid". Antibodies are a response to bacteria and viruses such as covid. Antibodies are proteins that protect you when an unwanted substance enters your body. Produced by your immune system, antibodies bind to these unwanted substances in order to eliminate them from your system. In diseases such as autoimmune diseases, such as SLE, the immune system gets confused between foreign bodies, such as viruses and its own body, causing inflammation while its antibodies attack its own cells.

After a positive test result, you may continue to test positive for some time. Some tests, especially PCR tests, may continue to show a positive result for up to 90 days. Reinfections can occur within 90 days, which can make it hard to know if a positive test indicates a new infection.

Why do some people test positive for extended periods of time?

It’s important to clarify which type of test we’re talking about in this situation. Studies have shown that some people can test positive for a month or more with a PCR test. The reason for this is twofold: PCR tests are capable of detecting extremely small amounts of genetic material, and fragments of the virus can remain in the respiratory system for a long time before being cleared.

When it comes to rapid tests, there are reports that some people test positive for an extended period of time with the current strains of the omicron variant compared with earlier variants. Several studies show that most people no longer test positive after five to seven days from their first positive test, but between 10% to 20% of people continue to test positive for 10 to 14 days.

But why it takes longer for some people to clear the virus than others is still unknown. Possible explanations include a person’s vaccination status or the ability of one’s immune system to clear the virus.

In addition, a small number of people who have been treated with the oral antiviral drug Paxlovid have tested negative on rapid antigen tests, with no symptoms, only to “rebound” seven to 14 days after their initial positive test. In these cases, people sometimes experience recurring or even occasionally worse symptoms than they had before, along with positive rapid test results. People who experience this should isolate again, as it has been shown that people with rebound cases can transmit the virus to others.

Ray46 profile image
Ray46 in reply to lupus-support1

Well firstly I'd say when in doubt about covid, phone your doctor before seeing them...

Then I think maybe the poster maybe was asking if they were still testing +ve because of antibodies - which is a definite no, but some lateral flow tests are labelled "antigen" tests and some people confuse the two (antibody tests are something quite different).

As you say, this sounds like rebound case after paxlovid. I can personally confirm long +ve times - when my wife brought it back as a present for me earlier this year I was +ve for nearly 14 days, incubation time was long too, 5 days I think (was isolating as I knew when she went +ve I'd been exposed, a lot, and was 24hrs off calling it a successful avoidance). My wife got the pax (I didn't) and she was -ve inside a week and stayed that way.

Raw57 profile image
Raw57

I have had Covid once. I tested positive for around 2 weeks, maybe longer. I did not take paxlovid. I did the at home rapid test. My doctor said after 5 days I was not contagious but I separated myself from my family for a week but I did not leave the house accept to sit outside until I tested negative. My husband and son did not get Covid from me.

I remember the constant positive tests upsetting but now I’m not sure it would bother me. I did feel sick but not as bad as I have been with the flu years ago.

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