Since lately we have been talking about resensitizing ourselves to ARPIs and other solutions to delay more drastic interventions, I remembered about ORIC-944 (sometimes my memory suprises me, considering ADT )
I have already written about this, on my blog but I think also here (surely on the other PC community)
clinicaltrials.gov/study/NC...
prostatewarriors.com/2025/0...
This is an option for people who had a PSA rise while on ARPI, they also have an extended access (compassionate use) policy even if not outside the USA, but their trial should start recruiting patients in Europe soon.