In vivo: Nodularin-R Enhances Abiraterone's Effectiveness Against Castration-Resistant Prostate Cancer

[Maxone73]

another door opens, hopefully a good one…

Researchers found that high expression of the PPP1CA gene is linked to a worse prognosis for patients. They discovered that silencing PPP1CA made cancer cells more susceptible to abiraterone, while overexpressing it had the opposite effect. This suggests that PPP1CA plays a crucial role in protecting cancer cells from abiraterone's effects. The study also identified nodularin-R, a natural product, as a potential inhibitor of PPP1CA. Combining nodularin-R with abiraterone resulted in synergistic inhibition of resistant cancer cells both in vitro and in vivo, indicating that nodularin-R might help overcome abiraterone resistance in CRPC.

prostatewarriors.com/2024/1...

[Shams_Vjean]

Nice find by these researchers. Hopefully there are less toxic natural substances which can provide the same or better results. Knowing what the target gene expressions are is an important first step.

Imagine how many who progressed on Abiraterone could benefit from a solution like this! Thanks for sharing this, Max!