Human Prostate Cancer Hallmarks Map - The PCa deep-dive guide

[cujoe]

As a comprehensive stand-alone PCa resource and a companion to Maxone73's just posted Nature paper on repurposing drugs, here is the ultimate tool to guide your deep dive into the drivers of PCa. It is called The Prostate Cancer Hallmarks Map and is an impressive piece of work by 3 Indian researchers. Here is the description of the Map in their own words:

Prostrate Cancer Hallmarks Map is an initiative taken from a system’s medicine perspective for detail systems level functional exploration of human prostate cancer specifically at molecular level with literature mined knowledge and insights. The principal aim of this project lies in the reconstruction of signalling pathway maps & altered circuitries of various cell biological events associated with the pathogenesis of human prostate cancer through a network medicine based approach. It represents signalling pathway based synthetic pictures of different prostate cancer hallmarks and their underlying oncopathological and cell biological features.

The Human Prostate Cancer Hallmarks Map is modeled from The Hallmarks of Cancer as defined by by Douglas Hanahan and Robert Weinberg in their paper of the same name published January 2000 in Cell, and updated in 2011 with the addition of 2 additional Hallmarks plus 2 "enabling characteristics" to make for a total of ten. As noted in the title, the Hallmarks are mapped as they apply specifically to the drivers of PCa. (The Drug Repurposing For Cancer Therapy paper uses a 2022 update to the Hallmarks that expands them to 14 elements and explores all types of cancers. For those unfamiliar with Hanahan & Weinberg's Hallmarks, I have provided links to the 2011 & 2022 publications mentioned above at the end.)

The Hallmarks used for the PCa Hallmarks Map are the ones listed below:

Self-sufficiency in growth signals

Insensitivity to anti-growth signals

Evading apoptosis

Limitless replicative potential

Sustained angiogenesis

Tissue invasion and metastasis

Deregulated metabolism

Evading the immune system

Genome instability *

Inflammation *

* enabling characteristics

As a resource, it provides a tabular listing of pathways and altered signaling functions in PCa. There is much here to explore and the table under the "Components" tab is very useful as a quick reference for identifying the characteristics of such pathways when mentioned in PCa research papers. The Comprehensive Hallmarks Map (shown above) is an illustration that diagrams all 10 PCa Hallmarks together.

Human Prostrate Cancer Hallmarks Map

bioinformatics.org/canjovdb...

Hanahan & Weinberg Hallmark papers:

Hallmarks of Cancer: The Next Generation, by Douglas Hanahan & Robert Weinberg, Cell, Review| Volume 144, ISSUE 5, P646-674, March 04, 2011.

cell.com/cell/fulltext/S009...

Hallmarks of Cancer: New Dimension, Cancer Discovery, by Douglas Hanahan, Review| January 12 2022.

aacrjournals.org/cancerdisc...

The further you push the boundaries of your own knowledge, the more of your own ignorance you will discover.

In the meantime, Stay Safe - Be Well,

Ciao - Capt'n cujoe

[MateoBeach]

Excellent Cujoe, thanks for this! I have long been oriented to the two "enabling factors" that underpin and drive all of the Hallmarks of Cancer Progression. Namely inflammation and genome instability (accumulating mutations). I note that several of the repurposed drugs fall into these categories. And I partake of them liberally. Paul/MB

[cujoe in reply to MateoBeach]

MB - Good to hear from you - and see your experience-based guidance inputs continue for those starting down the road of BAT. Our mutal friend in OZ and I both send you and the clan warm greetings for you to have a fine spring wherever you choose to spend it.

As always, Stay S&W,

Ciao - Capt'n cujoe