For curcumin lovers

[Maxone73]

I am guilty of loving curcumin as well, it's anyway great for many different aspects of out metabolism (like macrobiota health)

ncbi.nlm.nih.gov/pmc/articl...

[Ramp7]

I take curcumin on a regular basis. I've settled on a nano version that does not upset my GI and is supposed to be more bio-available.

[Maxone73 in reply to Ramp7]

you will love this then: pubs.acs.org/doi/10.1021/ac...

[Ramp7 in reply to Maxone73]

Many supplements people take are never absorbed into our systems just for this reason. That's a whole subject onto itself.

[Mascouche in reply to Ramp7]

When in doubt, just add black pepper to everything as it helps with the absorption of so many things such as curcuma, tomatoes, etc.... Some supplements already add it themselves under the name of peperine (which is basically pepper but without a double p )

[KocoPr in reply to Mascouche]

Youcan also put a pinch in DMSO mix well then add 50% of dmso volume with distilled water to mix. Then put it in your mouth for a few seconds a swallow.

DMSO will bring it right into the blood stream bypassing gut and liver

[Maxone73 in reply to Ramp7]

Can you tell me, even with a private message, what brand is this nano curcumin?

[Ramp7 in reply to Maxone73]

One Planet Nutrition Nano Curcumin 500 mg, Turmeric Curcumin Water Soluble Supplements, Nanoparticle-encapsulated. Purchased on Amazon.

[Maxone73 in reply to Ramp7]

Thanks!

[Mascouche]

I consume curcuma every day but stop using it 48 hours before a PSA test as it has been said that it can artificially make it look lower than it is. Doesn't mean that curcuma/turmeric does not benefit us of course. I do the same with saw palmetto, which is to stop using it 2 days prior to a PSA test.

[Maxone73 in reply to Mascouche]

I do the same!

[Nfler]

I haven’t but will try the 48 hour rule n see if there’s any difference in reduction of psa. I love the curcurmin and pepper 🌶️ is included in my Costco brand…

[landsailor]

I mash a tin of sardines(drained) with a teaspoon of turmeric, half a teaspoon of black pepper and four tablespoons of EVO.

[Maxone73 in reply to landsailor]

Still would not work. From what I have understood from the trials, normal curcumin from turmeric, even with added pepper, has a half-life of less than one hour and is dose independent....basically you can keep adding but the amount inside your blood won't change once reached a certain level. That's why there are nano-curcumin, liposomic curcumin and another ton of different formulations that are more stable and soluble. What's right for me...I still don't know

[MateoBeach in reply to Maxone73]

Two preparations with higher bioavailability also have clinical research showing significant benefits in humans (cognitive function not cancer specific). These are Theracurmin (nano preparation) and Longvida (Lipidized). Both appear to be clinically effective through whatever mechanisms. Don't know which might be better. I takke Theracurmin.

[Maxone73 in reply to MateoBeach]

I use theracurmin, then also simple curcumin + peperine, turmeric for cooking…I would like to try longvida as it’s a third generation curcumin supplement, theoretically even better than theracurmin.

[KocoPr in reply to Maxone73]

DMSO baby!

[Captain_Dave]

I have taken many curcumin types over the years. I have finally settled on micronized curcumin.

[Cooolone]

It is conceivable that this metabolic heterogeneity and flexibility makes cancer treatment, including targeting its metabolic liabilities, difficult to treat...

Herein lies the issue... Everyone is different. When reading thru the link, excellent by the way, it is easily identified that the compelling.data is difficult to mail down in regard to efficacy for any individual patient due to the heterogeneous nature of the disease itself. And we aren't quite there yet, ie, identifying individual patient cancer cell line predominance and those therapies with the highest efficacy for it. Mouse and Rat models don't count as 99.999% don't translate to human results, so there's that too. Anyways, good stuff to read thru. Disclaimer is I take Curcumin as well, lol, along with a few other supplements. My own set up, based upon my own research and discovery for what I want it to assist with in regard to diet and metabolism. Interestingly, no mention of hydrophilic or lipophilic differentiation either, which in my opinion has a great effect in regard to supplementation as well as drugs in general too.

Anyways, thanks for posting!

[Maxone73 in reply to Cooolone]

No prob, I agree with you. These studies are general guidelines, even clinical ones. I would contribute myself to a rigorous interventional clinical trial, especially about repurposed drugs. We are individuals but at the same time we share a common base, otherwise no medicine would work (their effect do differ on individual basis but for example "XYZ drug cures WXX diseases in K% of the population" is something that we look for).

I must say I panic when I think that maybe (and I say maybe):

a) a cure exists, but hidden because of some $$$$ interest...possible, very hard but possible, but I think that if there was a way to make a disease chronic companies would already be selling this drug as a chronic patient is more valuable than a dead patient;

OR

b) a cure exists, but it's sitting on some researcher table, waiting for funds (of for the will) to become a reality.

Oh well, I am going off topic here!

[Cooolone in reply to Maxone73]

I don't believe a "cure" exists... But today's medicine treats cancer more akin to a chronic condition! Longevity is key but sometimes dismisses quality of life in it's quest! Ultimately, if we exceed our stamped shelf life when born (life expectancy), have we then "won" or best the game? It's an interesting question to contemplate but when so many things can factor into that equation, ie, genomics, diet, lifestyle, general health, vocation, and more... There's no a single soul who could responsibly claim they've "cured" anything. I also believe it's a bit pompous of the medical profession the think they've conquered millennia of human biological development in a few short centuries and mostly decades in modern medicine. The more doors we open when we discover some mechanisms or other data, the more questions are created, not answered! It's all a conundrum...

So we do the best we can, with what we got at this time. Tomorrow might bring something different to try and roll the dice with, it's all good! I know and have watched BAT as an example go from maybe 3 studies, to so many now, I can't track it. And when there were just 3, it was taboo... No Oncologist would even like to discuss it with you. Lol. So things change every day!

[jazj in reply to Cooolone]

A cure does exist. It's called surgery or radiation (and cryo-ablation potentially in limited circumstances). What you guys are referring to as a "cure" is after failure of these other treatments.

[No_stone_unturned in reply to Cooolone]

Cooolone is absolutely right. I've been throwing everything and anything at this disease hoping that something works for me. I recently discovered Viome (p.s. not affiliated with this company or receive compensation for any promotion of their products) which claims to specifically analyze your biological homeostasis through a home test kit that you send in. It's a 3 fold test which involves a stool sample, blood, sample and saliva sample. It's a bit expensive (+- $300us) but if I think about how much I spend a month on supplements and food, I believe it will pay for itself. The point is everyones body is unique to their own biology. Someone who has been eating spinich their whole life thinking that its healthy for them, may be in fact be neutral or worse toxic to them while it may be beneficial to others. Point is, the only way to know what works for us is to test. Logically this checks all the boxes for me, so I decided to give it a go. I have not gotten the results back yet so I'll let you know what I think and if it was worth it. In the meantime, I continue to throw sh*t against the wall and sees what sticks because I have nothing to lose but money. If any of it works or not, I have no idea, but i do know that I'm starting my 4th year of a de-novo (stage4 at) dx and I'm still here, feel 20yrs younger than my biological age and my dr's say I don't look or act like someone who's in their 4th year of a terminal cancer. I'll take that! No stone unturned. WARRIOR ON....

[Maxone73 in reply to No_stone_unturned]

Yes please, it’s a very interesting test!