Beta Blockers.

[pca2004]

Interesting piece in the August Life Extension magazine.

Beta blockers inhibit progression in liver, breast, ovarian, pancreatic & colon cancer. Melanoma too, but conspicuously absent from the LEF list is PCa.

A few weeks ago, there was a PCa meta-analysis [1]:

"Ten studies met our inclusion criteria and a total of 74,970 patients were included: 26,674 beta-blocker users and 48,326 nonusers. There was no statistically significant association between beta-blocker exposure and PCa mortality".

Perhaps someone might offer a possible explanation?

The LEF article cited a 2021 meta-analysis for early-stage breast cancer [2]:

"In this meta-analysis, beta-blocker use was associated with a longer {recurrence-free survival} in patients with early-stage breast cancer, with a more pronounced effect observed in those with triple-negative disease."

However, no citation for general BCa. Cherry-picking?

-Patrick

[1] pubmed.ncbi.nlm.nih.gov/377...

[2] pubmed.ncbi.nlm.nih.gov/336...

[Justfor_]

In my case I was prescribed Beta blockers for Tachycardia inherited after long COVID. First month after taking them, while anticipating a PSA of 0.021-0.022, PSA nose dived to 0.005! Two monthly tests later with PSA stabilized at 0.010-0.011 I doubled the Beta blockers dosage so as to check for any dose to PSA decline relation. Early November next I will be able to report on the outcome.

[MateoBeach]

oIf a PCa patient is taking a beta blocker for blood pressure control they may do Much better to reduce PC progression and even metastasis by using an alpha blocker: doxazosin or prazosin. This has been well documented here in posts by myself and others.

[Justfor_ in reply to MateoBeach]

Long COVID is a very strange animal. It lowered my blood pressure and on the same time increased my pulse rate. Cardiologist prescribed this specific Beta blocker because it slows down the pulse rate with the mildest lowering of BP. And started me with the absolute minimal dosage.

[cigafred in reply to MateoBeach]

olf??

[Rolphs in reply to MateoBeach]

Are you taking Alpha blockers? I looked at your profile and didn’t see them on your RX list. My understanding is AB’s can really mess you up with SE’s. Low dose is better.

[MateoBeach in reply to Rolphs]

I added doxazosin and dropped amlodipine about six months ago to my BP regimen. The anti PC. Effects are well researched in. Cell studies, animal models and in humans. They are aside from the alpha blocking effects. These must be started at very low dose at nights to avoid postural syncope. After about a week you can titrate to BP effects. For me that ended up at two mg twice daily with doxazosin. No side effects. BPs run 120/60s.

[Rolphs in reply to MateoBeach]

Thanks for that update. I am going to investigate AB’s and talk over with MO.. I believe I was on this drug before but have to check. B/R

[PCaWarrior in reply to Rolphs]

I sometimes take a low dose of prazosin. I don't need it for BP reduction. BP is around 120 over 70.

At moderate doses it sedates me.

Numerous studies. It might be of particular benefit with RT. This trial might shed light on this: anzctr.org.au/Trial/Registr...

[Rolphs in reply to PCaWarrior]

Thanks for that information!

[Maxone73]

thelancet.com/journals/lanc...