I was thumbing through the Feb LEF mag & noticed that phellodendron tree bark was being touted as an inhibitor of monoamine oxidase B (MAO-B). MAO-B is an enzyme which breaks down dopamine. Our levels of the 'feel-good' neurotransmitter decline about 13% per decade after age 45.
MAO-B is also a target in Parkinson's & Alzheimer's.
I remembered that there was a product - Nexrutine - which was based on Phellodendron amurense bark extract, that was used in a number of PCa studies.
In fact, Kumar, et al, had 9 papers between 2006-2015 [1].
I used Nexrutine for a while, but the product seemed to disappear.
The same company had better luck with Relora, which was marketed as a weight control aide. That's a bit misleading, since it lowers the anxiety that sends some to the refrigerator in the middle of the night. Taken before bed, you wake up with lower levels of cortisol, the stress hormone. Useful when one has a lethal disease.
Relora contains Magnolia officinalis bark AND Phellodendron amurense bark.
Magnolia officinalis bark is the source of Honokiol, which has 16 PCa hits on PubMed [2]. (& there are other PCa papers that do not refer to Honokiol.)
Various brands sell Relora, so one should shop by price. e.g. [3].
You can also pay a lot for honokiol, or a little ($7.99) [4]:
Patrick thanks very much for posting. Do you think it is sensible to take both of the Swanson vitamins that you have helpfully provided links for. I currently take the eye wateringly expensive Honokiol from the same outfit that sells PectaSol. Is there any data on absorption of the cheaper Swanson version because I am thinking of switching.
I have long felt that the pricing structure at econugenics is predatory. Isaac Eliaz MD can get away with it when it comes to a unique product such as PectaSol, but does he hold a patent on Honokial?
I use Swanson Honokial, but I might be persuaded to switch to a more expensive brand if the company could present a strong argument, but I will never switch to the econugenics product.
Patrick, I took Honokial for years, I paid full freight for the good doctor's product. I switched to Swanson then to something I found on Amazon. Honestly, like most of the stuff I take, it never showed up on my blood tests. The two things that I think have: fenbendazole and 14 hours between my last meal and breakfast. Right now my latest experiment is powdered blueberries.
I’ve been taking a capsule of Relora daily for a couple of years as the plus appeared to outweigh minuses. Indeed seems no anxiety nor depression. But I’d need to drop it to see if any different. You could say I’m indifferent to it at this point.
Smurtaws links on MAOI-A inhibitors in PC are interesting. Maybe worth a try especially if one has become resistant to enzalutamide or perhaps ARV7?
Inhibition of signaling loop from “mothership” to bone, impairing metastasis is also noteworthy. Sonic Hedgehog (SHH) to RANKL in bone via IL7. That is also where denosumab is may also interfere with accepting metastasis.
Be very careful of many drug interactions with MAOI inhibition, including tyramine sources such as aged cheeses.
Do not eat foods that have dopamine and a high tyramine content (most common in foods that are aged or fermented to increase their flavor), such as cheese (especially strong or aged kinds), caviar, sour cream, liver, canned figs, soy sauce, sauerkraut, fava beans, yeasts, and yogurt. Avoid smoked or pickled meat, poultry, or fish, such as sausage, pepperoni, salami, anchovies, or herring. Do not eat dried fruit (such as raisins), bananas, avocados, raspberries, or very ripe fruit.
Do not drink alcoholic beverages. This includes Chianti wine, sherry, beer, non-alcohol or low alcohol beer and wine, and liqueurs.
Do not eat or drink too much caffeine. Caffeine can be found in coffee, cola, chocolate, tea, and many other foods and drinks. Ask your doctor how much caffeine is safe to use.
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