Consider Genetic Testing in All Metastatic Prostate Cancers— Expert panel recommendations from MedPage Today - June 10, 2020

[cujoe]

At last some definitive support for genetic testing for PCa patients. From the MedPage Today article:

"In addition to the recommendations for testing in metastatic prostate cancer and men with a family history of cancer, the consensus panel recommended that men who are BRCA2 carriers should begin prostate cancer screening at age 40 or 10 years before the youngest prostate cancer diagnosis in a family. Early onset of screening might also be considered for men who are carriers of HOXB13, BRCA1, and ATM."

"The panel also endorsed collaborative evaluation models for healthcare and genetic service providers to address the shortage of genetic counselors. The framework covers pretest informed consent, posttest discussion, cascade testing, and technology-based approaches."

Consider Genetic Testing in All Metastatic Prostate Cancers — Expert panel recommends testing for men with family history, selective testing for others

by Charles Bankhead, Senior Editor, MedPage Today June 10, 2020

medpagetoday.com/hematology...?

Get It Done, Guys. Be Safe & Stay Well - cujoe

[cujoe]

Agree 110%. The more we and our providers know, the better the decisions for treatment pathways. In my case, I would have expected many genetic aberrations, with both parents, all four siblings and two nephews with major cancer diagnosis - but the STRATA trial my cancer center got me into came up zeros for all 120 +/- defects?

Since those results were based on tissue from my prostate surgery in 2013, I'm saving Foundation One (or equal) for the day I might need to retest for newly acquired somatic mutations.

As always, thanks for you informed comments and I hope you are enjoying your summer in the mountains. BTW, when will you decide on ending your treatment vacation. You and Patrick stay out of trouble. (Or make it worth the consequences.) Later, K9

[marnieg46]

Nalakrats, would you mind explaining what Somatic Mutations are? Does it mean you can have genetic testing coming back quite clear of any issues and then something happens later?

[cujoe in reply to marnieg46]

This should explain it:

biologywise.com/germline-mu...

[marnieg46 in reply to cujoe]

Thank you cujoe. Much appreciated. I'll work my way through this information.

[marnieg46]

Thank you Nalakrats. I've re-read all the information... so could you indulge me if I've missed this.... but if the normal genetic tests are all clear, as cujoe has described and is the case for my husband, once a person develops metastasis and/or becomes castrate resistant is that when further genetic testing is conducted of say a biopsy of the metastasis, and then if somatic mutation is evident, does that alter the treatment to the type that might be suggested for those with germline mutation?

[marnieg46]

Understood. Many thanks. Much appreciated.