Non driving gene mutation-ASXL1

[merlisa]

I have MF with JAK2 V617F for 10 years, now is taking Ruxotinib and Interferon . Spleen contraction and blood control are good. Although I took a lot of hormones, at least my fibrosis degree has been reversed, and the mutation rate has also decreased a lot. But I was found I have a new bad prognosis gene mutation-ASXL1 with the rate of mutation is 15%~16%. What is the latest international approach to this mutation? I have no donor for stem cell transplantation, and I am extremely worried.