My son's neurologist prescribed increasing his Lamectil from the lowest dose to the highest with no gradual schedule. And, although depakote can interfere with Lamectil, he advised him to keep the depakote amount the same. We are concerned that this might lead to developing a rash which happened before when he had been taking both medications together for about 6 months. (Which led to dropping Lamectil completely until the rash went away). Any thoughts? Maybe I should add that the neurologist specializes in the treatment of stroke patients rather than Epilepsy. However, of the three doctors we've tried, he is the most interested in adjusting medications to try and eliminate seizures.