For those of us who hope for a cure within our lifetimes...
Basically, if you have 2 copies of a certain allele for tryptase, there is a strong correlation with also having EDSH and Mast Cell Syndrome.
The truly excellent news is that the body doesn't need tryptase - lots of people don't produce it, with no side effects, so just blocking it would be a possible fix!
I don't have Mast Cell problems with my EDHS, as far as I know, but then the symptoms of EDSH overlap hugely with MCAS, especially gut problems and heart beat issues. I do have a fine set of skin flushing and psoriasis anyway, so who knows?