THE MORE YOU DO THE MORE L-DOPA NEEDED ???

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I told my neurologist that my Madopar did not last as long if i was busy in fax a lot less .

Neuro said that is don't work like that.

Having thought about it I think he wrong. IF the neuro is rite and its a big IF .Why do we get

less L-DOPA at night or. when we are at rest . That is my ARGUMENT.

yours EXPORT.

[PatV]

He's way wrong. Mine wears off much quicker if I'm traveling, exercising or in a stressful situation. MJF said it. Also I've just had to up my meds by one or two. (Sinemet 25-100). Also getting off the sinemet CR because it gives me violent dyskinesia.

[wifeofparky]

My husband needs to add a 1/2 pill of his 25/100 sinemet if he does anything stressful or strenuous. Your doctor is wrong. Is he a Movement Disorder Specialist?

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Patv

Thanks for backing me up. If you don't mine.d me asking ,how old you are ?

i have very bad dyskinesia before I had the DBS op .

yours EXPORT.

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wifeofparky

Not the first nuero to say that is does not work like that . I said if you drive your car fast it take more petrol . A working man need more food the harder he works the more he needs .

Doctors only know what they have read or the likes of you and I have told them .

yours EXPORT .

[Dennis]

As I get worse my Neuro adds more C/L. 1/2 pill 2xday

[Yogibear]

EXTRACT FROM SINEMET - ASK THE PHARMACIST - forum.parkinson.org/index.p...

"Sleep and rest are so important for people with PD. It allows the remaining fun functioning dopamine cells to produce dopamine that can be "stored", if you will, because the body is not active. The more active the person is, the more muscle control they will need, which means the more dopamine will be used. In some people, just standing and walking can burn up much of their supply of dopamine.

Usually the more strenuous your activity is, the more you would use. It may not be linear in all people. A sudden burst of muscle use, let's say lifting a heavy box, can have the same effect as someone dong a lower impact project for a longer time.

I will let you know that it seems like walking has the least amount of affect on dopamine loss. Die to the fact you use mostly your leg muscles which are strong, and you usually walk at your on pace. If you were to run, you use more muscles and more dopamine would be used up.

Also, very small tasks like woodworking, painting, drawing, etc... seem to speed up the lose of dopamine also. Mainly because you are using a great deal of muscle control to do these types of tasks. So, I have found it best to do a little, take a break, and then go back at it."

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Yogibear I agree with most of what you say . I don't think dopamine can be stored as it a compound present in the body as a neurotransmitter there for having no life .I could be wrong unlike doctors I will hold my hands up if i am wrong.

yours EXPORT.

[olpilot]

I've been wondering about this too. For the last several years, before was diagnosed, I was so tired, had no desire to do anything. Now it seems when the meds start to to work I get moving more, but the more I do, the sooner I start to go down hill. Same with stress, or any big change in routine, it seems to hit off sooner. Right now just requip and azilect, but I still get very tited especially from mid day requip. Morning feel like I'm ready to go, afternoon requip, at about 1 hour, BAM, I can't just sit, or I'm out. Evening ok. I think I need a way to even things out, going to talk to dr about requip xl. I have some lower dose requip left from titration and some times at night I take one because I just need something to push past that off, going to talk to dr about that in abiut 10 days. I'm a little afraid of taking the pills, but I can sleep much better. When it wears off at night sometime I can feel my heart beat throught my body. An extra mg of requip will stop that, and an occational attack of feeling like I can't breath.