Stress can dramatically increase the ability of chemicals to pass through the blood-brain barrier , the complex system of blood vessels that protects the brain from toxins circulating in the bloodstream.
During the Gulf War, to protect themselves from chemical and biological weapons, Israeli soldiers took a drug called pyridostigmine. Nearly one-quarter of them complained of headaches, nausea, and dizziness – symptoms which occur only if the drug reaches the brain. Pyridostigmine molecules generally can't get into the brain, so why had the side-effects increased during combat?
An Israeli biochemist and physician wondered whether the stress of war might somehow have increased the permeability of the blood-brain barrier. The two researchers took a group of mice and stressed some by dunking them in water. They then injected the rodents with a dye and measured its intensity in the autopsied brains. They found that the dye had passed much more readily into the brains of the stressed animals.
The fact that stress can dramatically increase the ability of chemicals to pass through the blood-brain barrier has enormous implications, since many drugs are developed under the assumption that they will not enter the brain.24
And if Parkinson's was not a brain disease, but ... an infectious disease, a pathogenic trigger in the intestines? this hypothesis "incredible" is starting to become credible
AND I HAVE JUST RED IT TOO - I SUFFERED FROM A BAD ATTACK ( MY FIRST ) OF DIVERTICULITIS - A BOWEL INFECTION, BACK IN 19 95 - I WAS HOSPITALIZED AND IT WAS FOUND OUT THEN - HOW GREAT WOULD THIS BE IF IT CAN BE PROVED THAT IT IS AL IN THE BOWEL TO START WITH - THE SECOND BRAIN ?
OMG I have something like that NOW! I completely believe there is a connection. Have you had a recurrence? Do you have PD? It's getting worse and worse! And no doctor seems very interested.
A health writer friend was pushing the fecal implant technique on me! Ew. There's no one I can think of to donate. Plus the process to get ready for it sounds very arduous and STRESSFUL. I'd almost rather go through surgery
WOW this is whAT I HAVE BEEN SAYING TO MY NEURO FOR WEEKS AND WEEKS I READ SOMEWHERE ABUT A CHAP WHO WAS TREATED WITH ANTI BIOTICS AND WAS CURED OF HIS PD - IT WAS AN AUSTRALIAN RESEARCH COMPANY IN SYDNEY WHICH ARE DOING THE RESEARCH
There is much research on helicobacter which has been implicated in causation of PD
Helicobacter pylori, a bacterium that lives in the stomachs of about half the people in the world, may help trigger Parkinson’s disease, researchers report
Some previous studies have suggested that people with Parkinson’s disease are more likely than healthy people to have had ulcers at some point in their lives and are more likely to be infected with H. pylori. But until now those connections between the bacterium and the disease have amounted to circumstantial evidence.
Now researchers are gathering evidence that may pin at least some blame for Parkinson’s disease on the notorious bacterium.
Middle-aged mice infected with the ulcer-causing bacterium developed abnormal movement patterns over several months of infection, said Traci Testerman, a microbiologist at Louisiana State University Health Sciences Center in Shreveport. Young mice infected with the bacterium didn’t show any signs of movement problems. Testerman’s colleague, neuroscientist Michael Salvatore, found that Helicobacter-infected mice make less dopamine in parts of the brain that control movement, possibly indicating that dopamine-making cells are dying just as they do in Parkinson’s disease patients.
The bacteria didn’t have to be alive to cause the problem. Feeding mice killed H. pylori produced the same effect, suggesting that some biochemical component of the bacterium is responsible.
A candidate for the disease-causing molecule is modified cholesterol. Helicobacter can’t make its own cholesterol, so it steals cholesterol from its host and then sticks a sugar molecule on it. The structure of the modified cholesterol resembles a toxin from a tropical cycad; people in Guam who have eaten the plant's seeds have developed a disease called ALS-parkinsonism dementia complex. Testerman and her colleagues are trying to determine if the modified cholesterol alone can lead to Parkinson-like symptoms in mice or if some other factor from the bacterium is also needed.
Even if the scientists show that H. pylori can cause or contribute to Parkinson’s disease, it’s not clear whether getting rid of the organism would be a good thing. Although the bacterium causes ulcers and stomach cancer, it also helps protect against allergies, asthma and esophageal cancer and other acid reflux diseases. It is hard to know at this point exactly how letting Helicobacter stay or making it go will affect any individual person, said microbiologist Stanley Maloy of San Diego State University. But it is clear that a possible link between Parkinson’s disease and the stomach bacterium can no longer be ignored.
I have suffered with H Phlori on a number of occasions and asked a question some time to see if anyone else had had a similar complaint. I was treated with high doses of antibiotics and it came back a couple of other times.
This is very interesting as it could be a clue as to why I have Parkinsons. It seems to be too much of a coincidence for there not to be a link.
Wow, I also have been treated for H. pylori. Once before I had PD and once after knowing I had PD. I also am taking meds for acid reflux.
Thank you PURPLEPIXIE your information was very helpful!!!
I'm going to show this to all my doctors and in the meantime seek natural cures. Scary specially with link to stress. I was in a stressful marriage for 31 years and I'm surprised I didn't show symptoms before age 62!
PurplePixie do you have a link to the article which you have shared with us in your post. I want to send it to a friend and I know she will ask the source. Thanks!
I am a huge believer int he gut-brian connection and healed my son's severe developmental delays by healing his gut.
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