Kenai facility will boost Parkinson’s neuron replacement research

[Boscoejean]

I am posting this for informational purposes only. I do not know what the implications of this will be.

parkinsonsnewstoday.com/new...

parkinsonsnewstoday.com/new...

"RNDP-001, developed by Kenai Therapeutics, works by replacing lost neurons in the brain through a cell replacement therapy, utilizing induced pluripotent stem cells (iPSCs) to generate off-the-shelf neurons that can be transplanted into patients, aiming to treat neurodegenerative diseases like Parkinson's disease by essentially "repopulating" affected brain regions with functional neurons; this mechanism of action offers the potential for a curative treatment by restoring lost neural connections and function.

Key points about RNDP-001's mechanism:

iPSC technology:

The key to RNDP-001 is the use of iPSCs, which allows scientists to generate patient-specific neurons from readily available cells, potentially overcoming issues with immune rejection.

Neuron replacement:

The therapeutic strategy involves transplanting these generated neurons into the affected brain areas where neurons have been lost due to disease progression, aiming to restore neural circuitry.

Potential for disease modification:

Unlike many current treatments that only manage symptoms, RNDP-001 has the potential to modify the disease course by directly replacing damaged neurons."

"When delivered to the brain, RNDP-001 has the potential to halt disease progression, rebuild neural circuitry and restore lost cells in order to return patients to an earlier stage of their disease."

kenaitx.com/#science

Personally I would like to know about the entire process that these people are using but so far I have not been able to find it however that doesn't mean I won't persist in this search.

I was not able to find research on clinicaltrials.gov with regard to this treatment

RNDP001 has advanced from discovery to pre-clinical

[Boscoejean]

further research being undertaken by Kenai

iPSC | Dopamine Neuron Progenitor

INDICATIONS

1 Moderate to Severe Parkinson’s Disease

2 Inherited Parkinson’s Disease*

*Sponsored by grant funding from the Michael J. Fox Foundation (MJFF)

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RNDP-002

PLATFORM

Gene-Modified iPSC | Dopamine Neuron Progenitor

INDICATIONS

Mild to Severe Rapid Progressing Parkinson’s Disease

-----------------------------------------------------------------------------------------

RNDP-003

PLATFORM

Gene-Modified iPSC | Dopamine Neuron Progenitor

INDICATIONS

Young Onset Parkinson’s Disease

[Boscoejean]

"Kenai Therapeutics does not utilize embryonic stem cells; instead, they use induced pluripotent stem cells (iPSCs), which are derived from adult cells like skin or blood, to develop their cell therapies for neurological conditions like Parkinson's disease.

Key points about Kenai Therapeutics and stem cells:

Focus on iPSCs: Their primary technology revolves around using iPSCs to generate replacement neurons for treatment.

Neurological diseases: Kenai aims to develop off-the-shelf neuron replacement therapies for various neurological conditions.

No embryonic stem cells: They do not use embryonic stem cells in their research or development. "

[park_bear]

Pre-clinical means as of yet they're still investigating safety for use in humans.

[gomelgo]

sounds like this is definitely one to watch, eh?