"Studies indicating the administration of vitamin D3 as a supplement. Vitamin D significantly improves posture in patients with PD when administered daily"
Understanding the role of "sunshine vitamin D" in Parkinson’s disease: A review
Vitamin D levels are low in patients suffering from PD, and boosting vitamin D levels indicates the possibility of improving mood, cognition, and behavior in PD patients along with preventing the aggravation of PD symptoms. The review convinces us to accept the fact that improving vitamin D levels reduces the incidence of fractures, especially hip fractures, and recovers bone density as well. At the same time, certain limitations that need to be taken into consideration for further research include the necessity to establish the effectiveness of vitamin D3 as a supplement in PD, and determining the correlation between vitamin D3 and PD will be crucial because vitamin D can act as a biomarker for PD. Also, deficiency of the vitamin has become frequent across the globe, and supplements of vitamin D are easily accessible and affordable. Thus, vitamin D can act as a potential candidate that can be used as a supplement in PD; however, another limitation to be taken into account is its toxicity profile, especially in PD subjects, and at exactly what stage of the disease is the supplementation useful."
"Unrecognized vitamin D3 deficiency is common in Parkinson disease
I kind of wonder what is meant by this conclusion- does it mean that 75-100 are somehow beneficial and that other amounts are not beneficial? I ask this because it mentions optimal survival rates.
"Conclusion: Serum 25(OH)D levels are nonlinearly linked to mortality in PD patients, with optimal survival rates occurring at 75–100 nmol/L. Deviations from this range increase the risk of death."
Yes, it means that the optimal is 75–100 nmol/L (that's 30–40 ng/mL). But it's an association study. It might not be causal. Still, it doesn't argue in favor of supplementing (unless really deficient).
While sun exposure is a source of D3 it seems like it is important to do this carefully:
"To optimize vitamin D3 production, aim for 10 to 30 minutes of sun exposure on exposed skin several times a week, particularly during the midday hours when the sun's rays are strongest.
However, it's crucial to balance vitamin D production with sun safety to minimize skin cancer risk.
Here's how to strike the right balance:
1. Limit Sun Exposure:
Avoid prolonged sun exposure, especially during peak hours (10 am to 4 pm).
Use sunscreen with an SPF of 30 or higher, even on cloudy days.
Seek shade during peak sun hours.
Cover exposed skin with clothing, hats, and sunglasses.
2. Optimize Sun Exposure for Vitamin D:
Expose skin to the sun for short periods (10-30 minutes) a few times a week.
Consider the time of day and your skin type when choosing sun exposure times.
In Oregon City, consider the seasonal variation in UV intensity and adjust your sun exposure accordingly.
3. Supplement with Vitamin D:
Consider a vitamin D supplement if you're concerned about adequate intake.
Consult your doctor for recommended dosage based on your needs.
4. Skin Cancer Prevention:
Check your skin regularly for any changes, including moles or growths.
See a dermatologist for regular skin checks.
Be aware of your family history of skin cancer.
Additional Tips:
Use sun-protective clothing and accessories.
Avoid tanning beds, as they are linked to increased skin cancer risk.
Be mindful of the UV index, a measure of the sun's intensity. "
Skin cancer in Parkinson's - how it may happen:
"Alpha-synuclein (α-syn), a protein implicated in Parkinson's disease, has been linked to melanoma (skin cancer) through research suggesting a potential role in its development and progression.
Mechanism:
Melanin Disruption:
α-synuclein may interfere with melanin production, the pigment responsible for skin color. This disruption could potentially increase susceptibility to UV radiation-induced damage, a key risk factor for melanoma.
Iron Metabolism:
Studies suggest that α-synuclein influences iron metabolism in melanoma cells, potentially contributing to cancer cell growth and proliferation.
Cell Growth and Motility:
Research indicates that α-synuclein may impact cell growth and motility in melanoma cells. Knocking out α-synuclein in melanoma cells has been shown to reduce tumor growth and metastasis.
Melanoma Risk Factors:
While the exact mechanisms are still under investigation, α-synuclein's role in melanoma development might be linked to its influence on pigmentation, iron metabolism, and cell growth.
Parkinson's Disease Connection:
The association between α-synuclein and Parkinson's disease is well-established, and studies show that people with Parkinson's disease may have an increased risk of melanoma.
Shared Pathways:
It's believed that shared pathways and genetic factors may contribute to the connection between α-synuclein, Parkinson's disease, and melanoma.
In essence, α-synuclein's involvement in melanin production, iron metabolism, and cell growth processes in melanoma cells suggests its potential contribution to the development and progression of skin cancer.
Further research is needed to fully understand the complex interplay between α-synuclein, melanoma, and other related factors"
The cancer risk is over emphasized, it may have been important in the days of the hole in the ozone layer but that has sine repaierd itself with te banning of CFCs. Many doctors now recomend daily unprotected sun exposure as long as no burning takes place. youtu.be/2hO7fniCbmw?si=pLx...
"Fish, particularly fatty fish like salmon, tuna, and mackerel, are a good source of vitamin D3. This is the same form of vitamin D that your skin produces when exposed to sunlight.
In essence:
Vitamin D3 (cholecalciferol): is the form found in fish and is also produced by your body when exposed to sunlight.
Vitamin D2 (ergocalciferol): is primarily found in plants, like mushrooms, and is less efficient than D3 at raising blood levels of calcifediol, the active form of vitamin D.
Therefore, fish are a good source of vitamin D3, not D2. "
D3 can be helpful in dental health with regard to the teeth and gums. Since Parkinson's can make dental hygiene more challenging it is likely good to have some assistance in this realm.
benefits:
"Vitamin D3 helps maintain dental health by regulating calcium and phosphorus absorption, which are important for strong teeth and bones. Vitamin D3 also helps prevent gum disease and tooth loss.
How vitamin D3 helps dental health
Stronger bones
Vitamin D3 helps the body absorb calcium and phosphorus, which are essential for strong bones and teeth.
Prevents gum disease
Vitamin D3 helps prevent gum disease by producing antimicrobial peptides and acting as an anti-inflammatory agent.
Prevents tooth loss
Vitamin D3 helps prevent tooth loss by supporting the jawbone and preventing osteomalacia, a condition that causes soft bones. "
"Enhanced dental hygiene is crucial for individuals with Parkinson's disease (PD) as they face unique challenges maintaining oral health due to motor difficulties and medication side effects.
Challenges and Strategies:
Motor Impairment:
Tremors, rigidity, and reduced fine motor control make brushing, flossing, and handling dental tools challenging.
Xerostomia (Dry Mouth):
Medications and reduced saliva flow can increase the risk of tooth decay and gum disease.
Dysphagia (Difficulty Swallowing):
Swallowing difficulties can increase the risk of aspiration pneumonia, a serious complication.
Denture Care:
Denture wearers may struggle with cleaning and maintaining dentures.
Enhanced Hygiene Strategies:
Adaptations: Use electric toothbrushes with large handles and soft bristles, floss holders, or water flossers.
Simplified Routines: Brush after meals, even if rinsing with water is easier than brushing.
Medication Timing: Schedule dental appointments around medication times to minimize symptoms.
Professional Care: Regular dental check-ups and cleanings are essential.
Dry Mouth Management: Use fluoride toothpaste, gels, and mouthwashes to combat dry mouth.
Denture Care: Clean dentures regularly and ensure proper fit.
Oral Health Resources for PD:
Parkinson's Foundation: Offers educational resources and support for dental care in PD.
National Institute of Neurological Disorders and Stroke (NINDS): Provides information about PD and its impact on oral health.
Local Dental Professionals: Find a dentist experienced in caring for patients with PD.
Local Support Groups: Connect with others and learn coping strategies.
Specific Tips:
Electric Toothbrush: Consider an electric toothbrush that is easier to hold and use.
Large-Handled Toothbrush: A larger handle can make it easier to grip.
Soft-Bristled Toothbrush: Soft bristles are gentler on gums and teeth.
Floss Holders: Use a floss holder if flossing is difficult.
Water Flosser: A water flosser can be helpful for cleaning between teeth.
Fluoride Mouthwash: Use a fluoride mouthwash to strengthen teeth.
Dry Mouth Products: Use toothpaste, gels, or mouthwashes designed for dry mouth.
Denture Care Products: Use denture cleaners and adhesives as needed. "
1. Laurie Mischley advised patients to maintain their D3 levels above 70, but in a recent video, she mentioned new research suggested between 30 and 40 as the optimal range of serum D3.
2. Vitamin D3 from sunlight is due to UV-B rays and are protective against cancer as is NiR. Cancer is caused by UV-A rays. Sunscreen blocks UV-B rays.
3. Vitamin D helps absorb minerals and deposit them in body tissue. Vitamin K2 helps to take the minerals to the right place for remineralization.
4. Flouride has been found to confer no additional benefit to enamel strength or dental health.
4.> There are studies suggesting that the effectiveness of fluoride may be overstated and that good oral hygiene and dietary choices are more important for dental health. However, research has shown that fluoride is indeed effective in strengthening tooth enamel and preventing tooth decay. It helps in remineralizing damaged enamel and reduces the activity of bacteria that cause tooth decay.
Fluoride as a neurotoxin has been proven in several animal studies. A 2006 National Research Council report stated that it is apparent that fluorides have the ability to interfere with the functions of the brain and the body by direct and indirect means.[19,20] This finding was confirmed by a study where groups of children exposed to 8 ppm fluoride in water were found to have lower average IQs, less children attaining high IQ, and more children affected by low IQ.[21] While 8 ppm is much higher than the fluoride level added to water in fluoridation programs (0.7–1.2 ppm), these results are in congruence with previous studies[22] from China that indicate that fluoride may affect IQ at lower levels.[23]
optimum levels of D3 is over 50-wrong guidelines for minimum is 30-40. As an example, if your VitaminDevel is above 50, you would not get Covid 19 as proven out by 30 studies done on over 500,000 people
I am focusing on acceptable level of D3- just had my annual physical and my level as always was, is and will be over 50- see Dr Julian Whittaker on his research on D3
I takes vitamin D3 supplement routinely - there isn't much sunshine to be had most days in England!
Some doctors seem to recommend it for all older people, others say the benefits aren't proven. But what's to lose by taking it?
Here's what NICE days, regarding falls and the risk of injury.:
1.1.12.5
Vitamin D. There is evidence that vitamin D deficiency and insufficiency are common among older people and that, when present, they impair muscle strength and possibly neuromuscular function, via CNS-mediated pathways. In addition, the use of combined calcium and vitamin D3 supplementation has been found to reduce fracture rates in older people in residential/nursing homes and sheltered accommodation. Although there is emerging evidence that correction of vitamin D deficiency or insufficiency may reduce the propensity for falling, there is uncertainty about the relative contribution to fracture reduction via this mechanism (as opposed to bone mass) and about the dose and route of administration required. No firm recommendation can therefore currently be made on its use for this indication. [2004, amended 2013]
The following text has been deleted from the 2004 recommendation: 'Guidance on the use of vitamin D for fracture prevention will be contained in the forthcoming NICE clinical practice guideline on osteoporosis, which is currently under development.' As yet, there is no NICE guidance on the use of vitamin D for fracture prevention.
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