palmitoylethanolamide + luteolin

[michelagvolpe]

Has anyone tried Palmitoylethanolamide + Luteolin since long time?

Any results?

[Salted]

I take PEA with Luteolin. It seems to help a lot. Initially, I took it daily for several months. When I ran out of it the last time, I decided I didn't need it. Within the next month, I experienced a lot more stiffness, less ease of movement, frequent headaches. I'm back to taking it daily. I feel better again. I think it helps me.

[Fed1000 in reply to Salted]

How many mg. do you take every day, 700mg?

[Salted in reply to Fed1000]

The brand I take, X Gold Health, is 2 capsules per serving, each serving contains 630 mg PEA and 30 mg Luteolin. The bottle says to take 2 capsules once or twice a day. I've been taking 2 capsules in the morning and one at bedtime.

[Possmenatt]

I have used PEA and luteolin for around 2years. I read to start at a higher dose ie 2 caps as per salted’s post but for me I take 1 cap in the afternoon. (650mg 50mg) I will try having a break for a short time at some stage . I happy with the dose at the moment 😃. I also was dx with severe spinal arthritis and scoliosis and one way or another I’m also still active and working in a manual industry. Overall since I been taking other supplements it would be difficult to completely attribute improvements to PEA but I would say at this time it seems to be effective for me and I will continue to keep it part of my stack. 😃

Ai Overview

Palmitoylethanolamide (PEA) and luteolin are compounds that may have a number of benefits, including:

-Pain relief: PEA is effective in managing pain and reducing inflammation.

-Improved cognitive function: PEA and luteolin may improve cognitive function.

-Improved sleep quality: PEA and luteolin may improve sleep quality.

-Reduced anxiety and depression: PEA and luteolin may help with anxiety and depression.

-Improved memory: Luteolin may improve memory.

-Improved olfactory function: PEA and luteolin may improve olfactory function.

-Reduced mental clouding: PEA and luteolin may reduce mental clouding.

PEA and luteolin may be particularly beneficial when taken together, as their pharmacodynamic properties complement each other. They may be effective in treating a range of conditions, including:

Alzheimer's disease, Parkinson's disease, Vascular dementia, Brain and spinal cord injury, Arthritis, ME/CFS, Fibromyalgia, and Long COVID.

[Zella23]

My HWP and I have been taking it for about 8 or 9 months now. I’ve osteoarthritis and it definitely reduced the pain in my joints. My HWP isn’t in too much discomfort, apart from a bad back that wasn’t PD induced. Even that isn’t as bad as it has been. We take the recommended 1 dose per day. No side effects noticed.

PEA SUPPLEMENT

[docjleonard55]

Been taking 1000 mg + 100 mg luteolin for 3 weeks now for severe shoulder arthritis as well as PD. Haven't noticed any effects so far (sigh).

[Possmenatt in reply to docjleonard55]

Hi docjleonard55. Strangely when trailing Pea I sensed it worked on my back and not on my shoulder unfortunately . My back has scoliosis and severe arthritis and my shoulder had arthritis, bursitis and torn tendons😃. Around 4 months ago I gave in and ended up with an injection of cortisone which worked a treat. I’ll have to reevaluate again soon but it(injection) in the meantime has kept me working 😃

I hope the PEA works for you’re shoulder docjleonard55 Maybe my dose was too low

[MarionP in reply to Possmenatt]

Okay, can you specify a little better because it is not clear from your comment whether you're attributing to help to pea or your cortisone injection, they could each be the "it" and "that" you referred to as helpful. Can you clarify that down a little better so we know whether it was cortisone or pea, or both maybe if that's the case but you should say so, and give some details as to the kind of relief you got from the pea? Or did the two kind of occur overlapping each other so you can't really tell which did the help?

[Possmenatt in reply to MarionP]

Hi MarionP. Sorry for the confusion. I took PEA long before the shoulder problem and I’m sure it(Pea Luteolin ) helped my back pain. 😃 I’ll have to wait and see if /when the cortisone wears off as I might then have to find a solution again for the shoulder

[MarionP in reply to Possmenatt]

👍🗿

[docjleonard55 in reply to Possmenatt]

Thanks for the response. I'm hoping that I just haven't taken it long enough. I already had a cortisone shot in one shoulder and it worked for a few months, but has come back with a vengeance. It interferes with my workout routines, as almost everything I do involves using my shoulders ( yoga, weight lifting, ping pong). I am looking into regenerative medicine, but I don't hold out too much hope.

[Bracondale]

Not got PD but have had 20 years of relapsing/remitting CFS (caused by mast cell activation/histamine release) and latterly IBS-D caused by antibiotics and worsened by covid infection. PEA (palmitoylethanolamide, not to be confused with phenethylamine also known as PEA) was one of the few items that I can definitely say had a noticeable difference on my symptoms! I took it as a mast cell stabiliser and it reduced inflammation (increased energy, improved cognitive function and sleep and decreased headaches/general aching of muscles and joints). A week after starting PEA I added luteolin and rutin (plus capers with lunch and dinner to provide quercitin). These are also mast cell stabilisers , luteolin particularly in CNS, rutin in the gut and quercitin generally. I understand PEA to be poorly absorbed so it ideally needs to be a micronised or liposomal preparation. It also has a short half-life so is best taken in divided dose through the day. I take this one (300mg) three times daily with food.

amazon.co.uk/Palmitoylethan...

[PD-Golfer]

I first heard about PEA (Palmitoylethanolamide) from some of the brilliant and dedicated minds at HealthUnlocked Parkinson's. After reading the paper from Dr Brotini (Brotini S, Schievano C, Guidi L. Ultra-micronized Palmitoylethanolamide: An Efficacious Adjuvant Therapy for Parkinson's Disease. CNS Neurol Disord Drug Targets. 2017;16(6):705-713. doi: 10.2174/1871527316666170321124949. PMID: 28325153), convinced me to take it (I started in 2022). PEA is a lipid, and it can be processed to make it more available to improve its adsorption capacity. Therefore, look for PEA that has been micronized or ultra-micronized.

The Brotini study is remarkable. Although a small-sized clinical trial, they found improvement in motor function of the Parkinson’s patients. The protocol was as follows: MDS-UPDRS clinical assessment was carried out monthly for three consecutive months before the actual trial began (times -3,-2,-1, 0). After that, um-PEA treatment (Normast, a medical food product available in Italy)) at a dose of 600 mg, two sublingual sachets for a total of 1200 mg um-PEA/day, were added to levodopa therapy (and eventually to other PD medication) for three months, followed by one sachet/day (total of 600 mg/day of um-PEA) for up to 12 months. Patients underwent MDS-UPDRS clinical assessment during um-PEA treatment at months 1, 3, 6, and 12.

Since I could not find Normast, I used another scheme: I initially took ultra-micronized PEA product from Elevations Terpenes. The white powder (1/2 teaspoon equal to ~800 mg um-PEA) was added to apple sauce or peanut butter, mixed up as well as possible, and ingested. I did this twice a day for three months. A direct communication from Dr. Brotini said I should use the um_PEA sublingually. It works well and dissolves quickly under the tongue.

Currently, I take ¼ teaspoon of the um-PEA powder sublingually in the morning and one of the X-Gold micronized PEA products; initially with Lutoelin, and more recently, I am now taking one capsule in the evening of micronized PEA/turmeric (curcumin). Turmeric/curcumin is used to reduce the inflammation in hip arthritis. The PEA powder (1/4 teaspoon is about 400 mg PEA) and PEA supplement (one capsule contains 300 mg PEA and 500 mg turmeric/curcumin) adds up to about 700-800 mg PEA/day and 500 mg turmeric/curcumin. As with all supplements, I try them to see how they work, then stop for a while and determine if there is a difference. I am back on the PEA protocol described above. It has some effect on pain and motor function. Here are the links to these products:

Elevation Terpenes- Ultramicronized PEA- tinyurl.com/mvwba9jf

XGold PEA and Luteolin tinyurl.com/55nxvuc8

XGold PEA and turmeric- tinyurl.com/29vyt5nc

And here are links to two blog posts on PEA:

journeywithparkinsons.com/2...

journeywithparkinsons.com/2...