Is this study on the Chinese herb jujube ... - Cure Parkinson's

Cure Parkinson's

26,521 members27,934 posts

Is this study on the Chinese herb jujube for Parkinson's et al common knowledge?

Tripple profile image
28 Replies

scienceblog.com/549175/anci...

Written by
Tripple profile image
Tripple
To view profiles and participate in discussions please or .
28 Replies
park_bear profile image
park_bear

Good find! Not common knowledge here at all.

I am pleased to be able to say this is a good study. That is actually a rare event. They used the A53T mouse, which is a valid model of Parkinson's. They used a low dose of jujube seed powder, Zizyphi spinosi, 0.1 mg per " shot" - so this was apparently injected. Edit - no it was not. See Bolt_Upright comment below. The human equivalent dose comes out to about 20 mg.

Study here: raw.githubusercontent.com/e...

elifesciences.org/reviewed-...

park_bear profile image
park_bear in reply topark_bear

The full name of this Botanical is Ziziphus jujuba Miller var. spinosa, per this article: news-medical.net/news/20241...

They use the hot water extract, which appears to be available at Amazon: amazon.com/BulkSupplements-...

amazon.com/Suan-Zao-Ren-Str...

Both products suggest one gram dosage. Reviewers of both products said it helped them to sleep, which would be a big plus for the likes of us. I placed the Bulk Supplements product on order, and plan to try one gram at bedtime. Some users report taking more. No reports of adverse effects found in the reviews.

Parkwarrior profile image
Parkwarrior in reply topark_bear

According to the report, the extract was not as successful as the ground up seed, so I tried to find whole seed that was not processed in any way. I had little luck at Amazon but did find it at a Chinese online grocery in New York called Po Wing Hong. They sell a 1 pound bag of seed for $26. Shipping is $10, but seems to be worth it since I ordered it this morning and my order has already been shipped. Here's the link:

powingonline.com/products/s...

Bolt_Upright profile image
Bolt_Upright in reply topark_bear

I don't think it was injected. Shot seems to be a feeding shot:

"Powdered materials of hot water extract, extraction residue, and non-extracted simple crush powder of ZSS were suspended in water at 0.33 or 1.65 mg/mL by sonication. 300 μL of each suspension (i.e. 0.1 or 0.5 mg material) was orally administered using feeding needles to male and female APP23, Tau784, Huα-Syn(A53T), and wild-type mice 5 days (Monday through Friday) a week for 1 month. "

park_bear profile image
park_bear in reply toBolt_Upright

Thanks!

Gcf51 profile image
Gcf51 in reply topark_bear

From the elife link:

"The hot water extract improved mouse memory, but the effect was incomplete (Figure 3A). In contrast, the simple crush powder markedly enhanced mouse memory to a level even higher than that of non-Tg littermates. Subsequently, the simple crush powder and extraction residue were administered to 8-11-month-old mice (mean body weight, 31.2 g) at 0.1 mg/shot for 1 month. Again, the simple crush powder displayed a strong effect on mouse memory (Figure 3B). On the other hand, the extraction residue showed only a moderate effect,"

Seems to me, we should be looking for crushed powder and not extract.

Gcf51 profile image
Gcf51 in reply toGcf51

There may be something in the beans that traditional Chinese water extraction doesn't extract. ie. oils....

Gcf51 profile image
Gcf51 in reply topark_bear

I found a product with "Full Spectrum Jujube Fruit, 675mg Caps". Google indicates 30 to 39 percent of fruit is seeds. I wouldn't think 175mg would be too much. I am assuming full spectrum fruit would include seeds, but maybe not you eat an apple and throw away the seeds.

Esperanto profile image
Esperanto

Thank you! It's surprising that we haven't identified this earlier at CP. While researching online, I came across numerous older studies that highlight the antioxidant, anti-inflammatory, and neuroprotective properties of jujube. These studies suggest that jujube extracts may help improve sleep quality, reduce anxiety, and enhance overall brain function, all of which are highly relevant for PWP.

I would love to plant a few jujube trees in my garden to harvest the red dates myself. However, I understand that they require a warmer climate to thrive.

Apollo84 profile image
Apollo84

The study states that the best way to take the seeds is by crushing them.

“Furthermore, when the seeds were simply crushed into powder and administered to the model mice, the team discovered that the cognitive function of the model mice recovered to a level above that of control mice. In addition, the powders apparently suppressed cellular aging in older mice and improved their cognitive function to a similar level as younger mice.”

Does anyone know where to get crushed Jujube seeds?

park_bear profile image
park_bear in reply toApollo84

Seeds are available at Amazon. You could crush them in a coffee grinder.

P1800 profile image
P1800 in reply topark_bear

Do you have a link😊I couldn’t find the seeds.

Thanks in advance

park_bear profile image
park_bear in reply toP1800

amazon.com/NHDCJF-Sour-Juju...

amazon.com/Ziziphus-Jujube-...

P1800 profile image
P1800 in reply topark_bear

Thanks a lot! It didn’t ship to Sweden that’s why I couldn’t find it.

If someone else has the same problem you can find it on ebay as well:)

Fed1000 profile image
Fed1000 in reply topark_bear

Do you have a link?

park_bear profile image
park_bear in reply toFed1000

see prior comment

Parkwarrior profile image
Parkwarrior in reply toApollo84

I bought whole seeds and will use a coffee grinder:

powingonline.com/products/s...

Esperanto profile image
Esperanto

Does anyone have experience with jujube seed as a supplement?

Oneworld23 profile image
Oneworld23

Thanks for bringing it to our attention. I have done some research and have ordered some of the powder from AmazonUK and will be trying this out. I will get back to you all in a few weeks time to share my findings

YoungPD-48 profile image
YoungPD-48

amazon.co.uk/gp/product/B0C...

thanks for sharing information, I have purchased 1 pack, will update once I will start using it

Fed1000 profile image
Fed1000 in reply toYoungPD-48

Thank you very much for link. I ordered too. Can you tell me howit should be taken and in what quantity?

gomelgo profile image
gomelgo

I'd like to give this a try. What would folks recommend to do with the powder? Mix in water or make into capsules? Some other way to take?

DogsWoode profile image
DogsWoode

Thank you all for your comments. Please keep us apprised, you forerunners of intelligent discerning thought. We pay attention to you folks on this difficult Parkinson's trek.

Jojaku123 profile image
Jojaku123

I have done a little research and it seems that some seeds are raw and some are cooked or fried. Which is preferable?

Chinamed profile image
Chinamed

Sounds like a great way to wreck your coffee grinder! After many years grinding herbs I can attest the VitaMix is one of the few tools can crack a nut as tough as that of the seed of the jujube 🙂

Sunsun99 profile image
Sunsun99

I’d like to try this too. I guess I would have to ask my dr this question but are there any interactions noted with other meds? (Ssri for example)

drumhead profile image
drumhead

Anybody find and organic jujube seed powder?

Possmenatt profile image
Possmenatt

Great find Tripple. I look forward to reading everyone’s trials 😃. For me EBay was the quickest for delivery and I’ve went for the seeds. I’ll crush when I get them.

250g Semen ziziphi spinosae Wild Jujube Seed suan zao ren sleep aid vege caps😃

Not what you're looking for?

You may also like...

Report on a Cleveland Clinic study involving the Pedaling for Parkinson's program (Jay Alberts et al.)

Individuals With Parkinson Disease Are Adherent to a High-Intensity Community-Based Cycling...
jeffreyn profile image

Is the Parkinson's honeymoon over for me?

History: I am 69, female, diagnosed in 2015,7 months after suicide of my soulmate (we were...
Jmellano profile image

Mannitol - is it the miracle for parkinson's disease...

In the last months there are a lot of indications that people in Israel are using mannitol for...
yigalm profile image

Israel Study on Parkinson's & Marijuana, very interesting. Does anyone know how I can get more in depth information on this study?

http://hemp.org/news/content/israel-study-shows-inhaled-marijuana-relieves-symptoms-parkinsons-disea
tlongmire profile image