GLP1 supplements

[Astronomer90]

There are some research regarding GLP1 agnostic helps with Parkinson's. There are a couple of trials in progress as well such as exenatide and lixisenatide. I came across this supplement for GLP1. Is it similar to GLP1 agnostic? Did anyone try GLP1 supplements?ca.iherb.com/pr/pendulum-gl...

[Rufous2]

GLP-1 agonists hold promise for PD, and probiotics is an interesting approach, but I'd be a little leery of that particular probiotic. The first ingredient, Clostridium butyricum, could well be helpful. It produces butyrate, a short chain fatty acid that benefits the gut wall and is considered beneficial in PD. Seems it increases gut levels of GLP-1; mdpi.com/2076-2607/11/6/1527

"C. butyricum exerts neuroprotective effects in various neurodegenerative diseases. In a PD mouse model, the oral administration of C. butyricum can improve motor deficits, dopaminergic neuron loss, synaptic dysfunction, and microglial activation. These neuroprotective effects may be related to the increased levels of colonic glucagon-like peptide-1 (GLP-1) and cerebral GLP-1 receptor, eventually restoring gut microbiota homeostasis [89]." 

The second ingredient, Akkermansia municiphila, I'd be a lot more trepidatious about. It's gotten a lot of interest for metabolic diseases, (it's low in type2 diabetes) but is found in high levels in people with PD. It's not certain yet whether it has a role in causing the disease, but it's capable of degrading the mucin layer of the gut and is associated with progression of disease, so it's not something I'd be willing to take.

nature.com/articles/s41531-...

"Similarly, gut microbiota predicted the progression of Movement Disorder Society-Unified Parkinson’s Disease Rating Scale (MDS-UPDRS) III scores in an early stage of PD with AUROC = 0.728. Decreases of short-chain fatty acid-producing genera, Fusicatenibacter, Faecalibacterium, and Blautia, as well as an increase of mucin-degrading genus Akkermansia, predicted accelerated disease progression."

There are some natural GLP1 agonists, of which berberine is probably the most well-known. This study mentions a few. It's only the abstract, but there's a decent reference list. link.springer.com/chapter/1...

"In the current study, we conclude that certain herbal-based constituents, such as berberine, tea, curcumin, cinnamon, wheat, soybean, resveratrol, and gardenia, can exert an influence on GLP-1 release."