Xenon inhalation to reduce L-Dopa-induced dyskinesia

[Bear1927]

michaeljfox.org/grant/xenon...

I have tried this therapy for 7 days about 2 weeks ago in Serbia, and it did work immediately but the effect is beginning to "fade" now.

Has anyone tried xenon or other any other gas?

[park_bear]

Interesting. Surprised an inert gas can have this kind of an effect. Reference: frontiersin.org/journals/ne...

[Bear1927 in reply to park_bear]

it was very effective, from the day 1

[Boscoejean]

"In particular, xenon was found to protect dopamine (DA) neurons in a culture setting where these neurons undergo sustained, low-level excitotoxicity mediated by glutamate (Lavaur et al. 2017), i.e., experimental conditions that model Parkinson disease (PD) neurodegeneration"

Neuroprotection of dopamine neurons by xenon against low-level excitotoxic insults is not reproduced by other noble gases

ncbi.nlm.nih.gov/pmc/articl....

Oral delivery of xenon for cardiovascular protection

"Cardiac hypertrophy often causes impairment of cardiac function. Xenon (Xe), a naturally occurring noble gas, is known to provide neurological and myocardial protection without side effects. The conventional method of Xe delivery by inhalation is not feasible on a chronic basis. We have developed an orally deliverable, effective Xe formulation for long-term administration. We employed 2-hydroxypropyl)-β-cyclodextrin (HPCD), which was dissolved in water to increase the Xe concentration in solution. The beneficial effects of long-term oral administration of Xe-enriched solutions on cardiovascular function were evaluated in vivo."

nature.com/articles/s41598-...

"Xenon is not approved by the U.S. Food and Drug Administration (FDA). This means that xenon can only be used in research studies. Xenon is a colorless, odorless gas used as a general anesthetic in Europe. Xenon has been used safely in adults and in children."

"Oral Xenon/alpha-Cyclodextrin Provides Neuroprotection for Ischemic Stroke"

while this article is with regard to stroke it does mention Xenon (Xe) has demonstrated powerful neuroprotective effects

cyclodextrinnews.com/2023/0...

[Bear1927 in reply to Boscoejean]

There are risks involved in this procedure, so its done by appropriately trained stuff. This treatment should be more accessible for people who suffer from Parkinson's.

[Boscoejean in reply to Bear1927]

I wonder how much research is being done so that this could become a more widely used treatment.

I went on clinicaltrials.gov and searched for clinical trials using xenon in Parkinson's and the only trial listed was one that is in Moscow/ Russia with an unknown status - a place that it probably would never be a good place to go because of the imprisonment policies.

I am beginning to think that there is a lot of research being done that never is listed on clinicaltrials.gov but then I should revisit a message I got a while back from a nurse friend who told me about a couple other sites that can be better to use when you are trying to find specific research - I need to write down those sites and see if they would be helpful in finding research that never seems to make it to clinicaltrials.gov

[Bear1927 in reply to Boscoejean]

Moscow is actyally a good place for xenon gas therapy, the only problem its mainly being used as "happiness drug" and there even were 2 death records, but if you really dig into them: one person was involved in politics and the second one had some big financial issues. So use of gas could have had nothing to do with their death. Personally I think real concern is quality and level of maintanance of equipment, since I already have tested the effectiveness of treatment I only need more money in order to do at least 1 month of inhalation therapy combined with fasting, parasite cleaning and intestinal bacteria repopulation.

[Boscoejean in reply to Bear1927]

I hope this works for you but personally I think it is very ill advised to go to Russia for any reason which is unfortunate because probably the people who are doing the research have some good goals. The US should probably restrict any US citizen from traveling there.

[Bear1927 in reply to Boscoejean]

I understand your war concern. The treatment I had was in Belgrade, Serbia. Not Russian Federation. I'm Ukrainian leaving in UK for the last 24 years:). I intend to do a "longer run" to see how long will it last. Also, one of the doctors that administered gas suggested to look at humming technique to raise internal nitric oxide levels

[gomelgo in reply to Bear1927]

Hi fellow Ukrainian, can you say more about this humming technique please? And where did you go in Serbia to have this procedure done?

[Bear1927 in reply to gomelgo]

Добрий вечір. Please have a look at these links:

youtu.be/Olupyse6rg0?si=kqP...(Not working as expected?)

youtu.be/rLwD7BGZUMc?si=II0...(Not working as expected?)

I went to this clinic:

vipvorobjev.com/en/dr-vorob...

[Boscoejean]

Research done in France -

Inhaling xenon ameliorates l‐dopa‐induced dyskinesia in experimental parkinsonism

Jérôme Baufreton, PhD, 1 , 2 Tomislav Milekovic, PhD, 3 Qin Li, PhD, 4 Steve McGuire, MS, 4 Eduardo Martin Moraud, PhD, 3 Grégory Porras, PhD, 4 Shiqi Sun, PhD, 3 Wai Kin D. Ko, PhD, 4 Marine Chazalon, PhD, 1 , 2 Stéphanie Morin, Bsc, 1 , 2 Elisabeth Normand, PhD, 5 , 6 Géraldine Farjot, PhD, 7 Aude Milet, PhD, 7 Jan Pype, PhD, 7 Elsa Pioli, PhD, 4 Gregoire Courtine, PhD, 3 , † Baptiste Bessière, PhD, 7 , † and Erwan Bezard, PhDcorresponding author 1 , 2 , 4

ncbi.nlm.nih.gov/pmc/articl...