I have posted this as separate to my previous post on CGAS STING however it is related as USP7 stabilizes cGAS and activates the cGAS-STING pathway, thereby assisting in its “over regulated” state. Again it’s about USP7 INHIBITORS.
As seems to be the common case with small molecule drug development, it’s impossible to ascertain what they are. Below is a link to a recent paper.
I’d try it but can’t find the right kind.
Pre-treatment before applying the toxicant is not a valid model of Parkinson's disease:
"Daily treatment was started 10 days before MPTP administration."
For more detail see:
healthunlocked.com/cure-par...
I've been thinking a lot about the use of mptp and the use of mouse models. It just doesn't seem to make sense to me that these are the same as human pd. Don't have the energy to write out my entire opinion. But the gist is that mice do not have the exact same nervous system and thought patterns that humans have. They don't seem to be beings who analyze themselves and their friends for example. And I do notice that when I analyze and then judge my nervous system gets agitated and tremors and pain increase.
The mptp objection I have is that it can be apparently reversed. And even if not, it is induced and not a natural result of say environment either external or internal. Therefore effects on mptp induced non judging and analyzing beings cannot possibly be considered indicative of effects in humans with pd.
Worse is that it is needless suffering and waste of collective time and money. Just my opinion so far.
Concern is understandable, but I think in the case of MPTP you might like to look up MPTP and MPP+ and read a bit to learn about their history and action. Spiking or pre-treatment is definitely invalid for an experimental intervention study, but you might find the chemistry behind MPTP itself and it's neurotoxic derivative which does the actual cell killing is not, it is quite relevant to what happens in humans and in mice, at least for purposes of interrupting that action in human dopaminergic cells. Best guess of course.
I have read more than I wanted to about mptp, thank you very much. Killing brain cells by deliberate toxic cocktail is not the same as what I am currently learning about PD.
The mechanism is the same, but If you insist, "deliberate" killing of brain cells isn't the same thing as "natural" causes and mice aren't people I suppose, if you like to argue it that way, it's a little more immediate and massive, but the mechanism is the same... (as I said, consider the actual mechanism of MPP+ (the actual molecule that does the killing in humans) and how it gets into those cells), and the great majority of PD cases occur by environmental intoxication by various industrial chemicals or their pharmaceutical equivalents done by recreation or treatment, those all seem sort of the same as "natural" given the great increase in incidence since the introduction of those chemicals...I'm not sure that the body knows the difference that you're making. Except for the small minority of genetic cases, they all seem to be either intentional or natural, the distinction seems to have little meaning. I'm sure you think it's a nice hypothesis and therefore, because you thought of it, you think it has merit (maybe it got you a little shot of dopamine). But arguing an unproved hypothesis, which you are doing, without evidence, doesn't make a lot of sense either, sort of adds a little automatic self-destruct to your original point.
Not sure whether it’s been discussed here but Microfluidics sounds promising.
ncbi.nlm.nih.gov/pmc/articl...
The MPTP model is not a great model but it is adequate if the toxicant is allowed to complete its evil deed before the test substance is applied. The downside of doing this is that most substances that work in pre-treatment will not actually work in a valid Parkinson's model.
Researchers who are really serious use the A53T mouse animal model of Parkinson's - It develops young onset Parkinson's similar to what humans experience with this mutation.
Update - Neuro appointment and Neupro!
Cold Laser and EMDR!
BioVie announces treatment of 1st patient in Phase 2 clinical trial of NE3107,ERK inhibitor that selectively inhibits neuroinflammation
Re fire ant venom "therapy?"
Work and Stress
