Antihistamines

[Grey_Area]

I seem to be able to find articles that say antihistamines are both good and bad...I've noticed when taking cetirizine for my hayfever that I get less "restless legs". Any further info?

[JayPwP]

You will find the same issue with many therapies / molecules 😆😆😆

[Rufous2]

That's interesting, hadn't heard of antihistamines lessening RLS. I did run across a study that used AI to screen existing drugs for those that might be useful in PD, and Levocetirizine was one of two antihistamines that showed promise.

ncbi.nlm.nih.gov/pmc/articl...

"The study objective was to use artificial intelligence to rank the most promising repurposed drug candidates for PD."

"The top predicted adjuvant PD therapies included ebastine, an antihistamine for perennial allergic rhinitis; levocetirizine, another antihistamine; vancomycin, a powerful antibiotic; captopril, an angiotensin-converting enzyme (ACE) inhibitor; and neramexane, an N-methyl-D-aspartate (NMDA) receptor agonist. Cross-domain text mining predicted that antihistamines exhibit the capacity to synergistically alleviate Parkinsonian symptoms when used with dopamine modulators like levodopa or levodopa–carbidopa. The relationship patterns among the identified adjuvant candidates suggest that the likely therapeutic mechanism(s) of action of antihistamines for combatting the multi-factorial PD pathology include counteracting oxidative stress, amending the balance of neurotransmitters, and decreasing the proliferation of inflammatory mediators."

[Grey_Area in reply to Rufous2]

Yep, I found that too, but also a number of articles suggesting antihistamines reduced the effectiveness of L-Dopa.

Also this from the ever present mayo clinic;

"Some of the antihistamines are also used to prevent motion sickness, nausea, vomiting, and dizziness. In patients with Parkinson's disease, diphenhydramine may be used to decrease stiffness and tremors. Also, the syrup form of diphenhydramine is used to relieve the cough due to colds or hay fever."