Annovis Bio Buntanetap

[JohnP65]

With the Buntanetap phase III trial dosing ending soon, I noticed that Annovis Bio stock is dropping like a rock. It is at a 52 week low. This makes me wonder if results are being leaked, and they are not promising. I hope I am wrong, and this is not another sham, but I can’t help but think about Annovis and the failed AD drug trial. Same thing happened, the stock value dropped sharply.

[park_bear]

I believe they are in need of additional financing which is also a possible reason for the decline

[PDTom in reply to park_bear]

but if Buntanetap works and the phase 3 trial is successful, it should be no problem to get money from investors.

I personally put a lot of hope in this drug.

Unfortunately, there are not many promising phase 3 studies.

This year I also had the feeling that not much has happened in research (pharmaceutical industry).

Here a new Youtubevideo from me...

youtu.be/FCpj432ycKo(Not working as expected?)

[park_bear in reply to PDTom]

Of course a good Phase 3 result would make all the difference in raising money. However, as it stands now they will run out of money by the end of the year. So if they're waiting for the result before raising $, analyzing the data will be a race against time, with dire consequences if the result is a disappointment.

With all that said, as pointed out below, the action in the biotech index fully explains the price action.

[Rupa88 in reply to PDTom]

wow, you are doing great🧿🧿🧿🧿🧿🧿🧿

Have you been in their trial?

Hiw long have you had PD?

[PDTom in reply to Rupa88]

parkinsonclub.de/en

[MBAnderson]

prospective investors are reading anecdotes on this forum.

[glanvill]

The entire biotech sector is down at the moment. The relevant index (XBI) is almost as low as it was during the Covid panic. I don’t think there is much to read into it.

[Pixelpixie]

I’m in the Trial and have seen no benefits but maybe I’m on a placebo or too low a dose. Hard to know

[gaga1958 in reply to Pixelpixie]

me 2

[jimcaster in reply to Pixelpixie]

Me too

[Btraveria1]

I’m in the trial and have seen significant improvements

[emstadler71 in reply to Btraveria1]

I did too! I have been off since July and definitely see a difference. I am really hoping for open label extension!!

[Btraveria1 in reply to emstadler71]

So am I. I’m afraid to go off!

[Pixelpixie in reply to Btraveria1]

What improved?

[Btraveria1 in reply to Pixelpixie]

Not dragging Right foot anymore, almost normal R arm swing, some more sense of smell, I can handwrite again, less R shoulder pain and some less tremor (unless under stress)

[emstadler71 in reply to Pixelpixie]

my response is almost identical. Probably the most significant change for me was getting an arm swing back again after seven or eight years of not having one! I had less tremor and I had virtually no off times. My score dropped from an 18 to an 8. And 8 is what it was at diagnosis! I felt better, I had more energy and I was exercising. Now that I am off I am definitely having off times and I’m actually looking to add something to my medication’s to supplement. One odd factor for me… I am a younger woman with Parkinson’s (52). I had been in perimenopause and had not had a cycle for two years. I started having cycles the month after the trial started and had my last cycle right as the trial ended. 🤷‍♀️

[Pixelpixie in reply to emstadler71]

so pleased for you. You might want to look into B1 therapy

[Pixelpixie in reply to emstadler71]

What improved?

[Ctime in reply to Btraveria1]

I was in the trial. Objectively at the end of the trial my C/L does was reduced by my neuro. Now an appointment 3 months post study, I am under medicated. Subjectively my sense of smell improved. In 3 months since, bradykinesia has worsened, mood and anxiety have worsened.

I would definitely do an open label trial

[Btraveria1 in reply to Ctime]

wow.. fingers crossed , as they say, for the open label trial for all of us participants. I am still currently on the medication , as my site started late. I am not looking forward to running out and doing without.

[gaga1958]

i am in the trial also and have not seen any improvement or difference

[111BANDIT]

Bio tech in general has been dropping like a rock. It has more to do with the availability of capital and interest rates since most biotech don’t have positive cash flow. To raise operating cash they generally issue shares which dilutes the value of shares in the short term.

[MarionP in reply to 111BANDIT]

True but if the product is a killer then that stock price is going to hold up much better than its peers because it will justify access to capital, and you will get this with the price indicator called "RP," which stands for relative performance. If rp is above 70 it's a good sign, and if it's above 80 it's a very good sign.

[Rupa88]

It was never promising to me

[MarionP]

Actually stock price action over time is not a bad indicator.

[Delaraysbest in reply to MarionP]

Over 300,000 shares traded yesterday at the lowest price all year. So there are buyers out there. Thankfully.n

[JohnP65 in reply to Delaraysbest]

Apparently they had positive data for Buntanetap in an AD trial. Hopefully there will be positive results for PD too.

[Delaraysbest]

They are planning a mid-November earnings release and update. Fingers crossed!