Parkinson's Discovery Suggests We May Already Have an FDA-Approved Treatment

[pvw2]

sciencealert.com/parkinsons...

"Promisingly, an FDA-approved cancer drug that targets another protein called Lag3 – which interacts with Aplp1 – blocks the spread in mice, suggesting a potential therapy may already exist."

[pmmargo]

link.springer.com/article/1...

[pmmargo]

Im sorry to repost. You are the first to spot this. And. this is big!

[jeffreyn]

See also this earlier thread:

healthunlocked.com/cure-par...

[Boscoejean]

this treatment is expensive:

"A 20 mL vial of nivolumab 240 mg plus relatlimab 80 mg, a fixed-dose combination, can cost around $8,315, with a treatment cost of $16,630 every 28 days. However, the price may vary depending on the pharmacy, and quoted prices are usually for cash-paying customers and are not valid with insurance plans. Drugs.com offers a price guide based on using their discount card, which is accepted at most U.S. pharmacies"

[Boscoejean]

Looks like more mouse studies before any human clinical trials.

"As of June 2024, the FDA has not approved nivolumab for Parkinson's disease, but a study suggests that it could potentially slow or stop the disease's progression in humans. The study found that nivolumab/relatlimab, an FDA-approved cancer drug, halted disease progression in mice. However, the researchers note that testing on mice differs from testing on humans, and that there are other limitations to their work. Further testing, such as human trials, could help confirm these findings."

"“The next steps would involve conducting clinical trials with the anti-Lag3 antibody drug in mouse models of Parkinson’s and Alzheimer’s diseases to further evaluate its efficacy and safety. If successful, human clinical trials would follow to assess the drug’s potential as a treatment for these neurodegenerative diseases. Additionally, [we] plan to investigate ways to prevent unhealthy brain cells from releasing disease-causing alpha-synuclein clumps in the first place, which could complement the approach of blocking their spread and uptake by healthy cells.”"

medicalnewstoday.com/articl...

[gomelgo]

Two words: "in mice". I don't think it's "big" after all. When they stop wasting time, money and lives, maybe humans can get a fair shake. Mice don't randomly get parkinson's. Only humans do.

[Eryl]

That's if you still believe that proteins are the cause of PD rather than the result of PD i.e the body producing the protein to patch up damage done by something else.