The 40 Hz flickering light restores synaptic plasticity and mitochondrial phenotype in experimental model of Alzheimer's disease May 2024 - researchgate.net/publicatio...
"Abstract:
Alzheimer's disease (AD) is the most prevalent form of dementia and a public health priority. The causes of AD are not completely understood. Pathogenetic factors including mitochondrial dysfunction, oxidative stress, reduced energy status, and compromised ion channels contribute to the onset and progression of the disease. Flickering light therapy in experimental and clinical AD has shown promising outcomes. However, the mechanisms behind the effect of flickering light at the molecular and cellular level has not yet been fully investigated. In this study, we established streptozotocin (STZ)-induced AD models by intracerebroventricular (ICV) injection of STZ in Wistar rats and monitored their memory decline. Sham and AD rats were either exposed or not exposed to 40 Hz flickering light for 7 consecutive days after 7 days of STZ injection. Memory and cognition-related behavioral analysis, pathological, electrophysiological, and biochemical assessment of the brain tissue, and mitochondrial function assays were conducted after the treatment. Cognitive and memory impairment, examined by Morris water maze (MWM), novel object recognition (NOR), and passive avoidance (PA) test, was observed in the STZ-induced AD rats and light treatment improved these behaviors. STZ injection led to significant accumulation of reactive oxygen species (ROS) and amyloid beta (Aβ), decreased serotonin and dopamine levels, and mitochondrial respiration. The 40 Hz flickering light reversed all these parameters in the light treatment group. The synaptic plasticity of STZ-induced AD rats was severely affected, but flickering light prevented the loss of synaptic plasticity and activity in the light-treated AD rats. Additionally, flickering 40 Hz white light elevated the levels of mitochondrial metabolites and the current and possible opening of the mitochondrial calcium-sensitive potassium (mitoBKCa) channel which were significantly downregulated in AD rat neurons. The 40 Hz flickering light restored mitochondrial function and synaptic plasticity of AD rat neurons and improved the cognition of animals; therefore, it can be a promising strategy to reduce AD progression."
Hi Bolt. I bought one of these flickering lights but it sent me crazier so I gave up and just used the ear phones . Then when I bought my omnipemf and discovered I could set it at 40Hz i used that. I still don't know if it works or not as I try so many things.
I tried 40hz. I started having vivid dreams. Dancing with blue smurfs was one thing. I knew it wasn’t real. But, dreams with real people and not being sure that something didn’t happen is another story. 🤪 crazy
I recently tried a 40hz light bulb from Amazon, but I found it very uncomfortable and had to stop using it. It just felt too intense, even when it was out of my direct line of sight.
I've been researching other options and came across the Evy light from Optoceutics. It's quite expensive, but I'm wondering if it might be a better fit for me. I reached out to the company and got a quick response explaining the differences between their product and the generic bulbs on Amazon.
Given my mild cognitive impairment and family history of Alzheimer's and Parkinson's, I'm seriously considering investing in the Evy light. I'm hoping it might offer some benefits without the discomfort I experienced with the bulb.
Has anyone else tried this? I'd love to hear about your experiences and any insights you might have.
Their Response:
Here’s how EVY LIGHT® stands out:
OC has developed a number of patents including Invisible Spectral Flicker (ISF). Unlike common 40 Hz light therapy devices that use simple strobe light technology, which can cause headaches, dizziness, and nausea, EVY LIGHT® employs our patented ISF technology. This makes the flickering barely visible, ensuring you receive the neurostimulation benefits without the discomfort.
Scientific Rigor and Research: EVY LIGHT® is backed by over five years of R&D and is supported by clinical studies. Our commitment to scientific validation ensures that you are using a device rooted in rigorous research and development.
Future ready software - The device comes with access to a mobile app allowing for goal tracking, data visualizations, user feedback, and will soon allow for a myriad of additional features, including; cognition tracking/measurement tools, provider integration and personalization, geared for the user, caregiver, and provider.
Our commitment to the customer experience : Access to a community of users, clinicians, educational resources, brain health experts and shortly an invitation to trial participation and access to the data
Onboarding, implementation, and on-going customer support to ensure you get the maximum value out the device and experience.
Money-Back Guarantee: We stand by the quality and effectiveness of our product. That's why we offer a 90-day money-back guarantee. If for any reason you are not satisfied with EVY LIGHT®, you can return it for a full refund.
There are a few companies who are building what I might consider to be cheap knock offs, manufactured with cheap non-medical grade components, a basic strobe light that can be difficult for most to tolerate. EVY LIGHT® offers a superior, scientifically-backed experience with personalized support and advanced technology that ensures comfort and effectiveness.
TY Well I'm working through some of them now. Meanwhile, Juan wants to know the very most important thing on the front of the website, after of course being impressed by all the MD PhD combinations and magnificent named institutes of research an incredibly polished marketing effort:
Claims regarding the effectiveness of EVY LIGHT® and 40 Hz light are based on ongoing research and have not been conclusively proven. EVY LIGHT® follows the published guidelines by FDA for low risk general wellness products and is not subject to FDA medical device regulations. EVY LIGHT® is not intended to diagnose, treat, cure, or prevent any diseases or medical conditions.
That video won't flash at 40 HZ on most devices. I don't remember the details. Maybe some fancy Apple screens have a high enough refresh rate, but most don't.
Have you ever wondered, what subconscious effect has the power-grid played on the human brain, over the last century with its 60hz (50hz in Europe)? Electricity wasn't available to the masses until the 1920's. And, if they had chosen 40hz instead, would we be having this conversation.
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