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News very important

SereAve•

12 days ago•22 Replies

rainews.it/amp/articoli/202...

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Nitro5312 days ago

English please

chartist12 days ago

This is discussing the positive effects of micronized PEA in PD.

This is the translation :

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Neurologist Brotini: "Neuroinflammation precedes the disease"

Mariavittoria Savini

World Parkinson's Day is celebrated every year on April 11, the day of the birth of Dr. James Parkinson , famous for first recognizing the disease as a medical condition. The anniversary is an opportunity for discussion for patients, families and healthcare workers with the aim of increasing knowledge about the disease and its impact on individuals, their caregivers and their communities. In Italy, there will be around 300 thousand Parkinson's patients in 2023, as reported by the Rare Diseases Observatory.

The pathology

Parkinson's disease represents the most common neurodegeneration among movement disorders . The causes are not known: environmental ones are suspected and a "familiarity" is often found . It frequently occurs around the age of 60, but it is not a disease of the elderly and increasingly affects young people. About 10% are people under 50 . The best known of the symptoms is tremor , but so are slowness of movements, muscular rigidity, a certain inexpressiveness of the face, and difficulty in writing. Some symptoms such as reduced sense of smell, sleep disturbances, depression and constipation (tiredness) can precede the onset of movement disorders by years. But it is difficult to relate them to Parkinson's.

Today "there is substantial evidence on the role of neuroinflammation in the mechanism that leads to the death of nerve cells at the level of the dopaminergic system. The underlying mechanism is determined by an increased vulnerability of dopaminergic neurons to various neurotoxic insults, which can determine neuroinflammation. In this context, numerous scientific data underline the role of neuroinflammatory phenomena in the uncontrolled progression of pathologies such as Parkinson's" explains S tefania Brotini , neurologist at the San Giuseppe hospital in Empoli.

The treatment

There is currently no known cure for Parkinson's . However, various pharmacological therapies are available which, especially in the early stages, guarantee good control of the symptoms: there are many drugs available, and the choice of the best combination is made by the specialist neurologist, taking into account the patient's characteristics.

Scientific research

" Research on Parkinson's disease in recent years has been dedicated to the study of neuronal pathology , but also of all other non-neuronal cells. Among these in particular microglia and astrocytes, which represent the main protagonists in the neuroinflammatory process. What what emerged is that, contrary to what we believed in the past, the neuroinflammatory process arises before the degeneration of neuronal synapses, which means that it is not the consequence as we believed in the past. Therefore the degeneration of Parkinson's is secondary to chronic neuroinflammation and not vice versa ", explains the expert. This discovery led to the study of lipid molecules that may play an essential primary role in combating chronic neuroinflammation. "These include ultramicronized Palmitoylethanolamide (PEA-um), which is able to counteract harmful phenomena affecting the central nervous system. Endogenous PEA counteracts the onset of neuroinflammatory phenomena through the inhibitory control of non-neuronal cells, when these are hyperactive", she explains.

"We studied the exogenous administration of PEA-um in a group of parkinsonian patients. The results were exciting: the dyskinesias were significantly reduced and there was also an increase in the duration of the dopamine effect - says Brotini - In addition in fact, Pea-um can be an effective adjuvant to classic therapy to reduce involuntary movements or the duration of motor block. It therefore reduces the side effects of the disease and of traditional therapy and delays the course of the disease even in the advanced stage In summary, the addition of ultra-micronized PEA demonstrated a notable improvement in motor symptoms, but also in many non-motor symptoms."

World Parkinson Day Stefania Brotini

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Art

Bolt_Upright in reply to chartist12 days ago

The successful studies used um (ultra-micronized), not micronized. I use micronized as it is easier to manage, but I also have um and should really be using that.

Hope-full1970 in reply to Bolt_Upright12 days ago

I'm all set, I found it. It's just like it says PEAI have not heard of it before .

Hope-full1970 in reply to chartist12 days ago

Hi Bolt,Could you tell me what um-PEA would be in a supplement form? Thanks!

Bolt_Upright in reply to Hope-full197011 days ago

I use the micronized usually, but I also have this and should use it more: USA LAB Tested Bulk Ultra-micronized Palmitoylethanolamide Powder 99% Pure (250 Grams) $100 amazon.com/gp/product/B07NJ...

According to my scale, 1/2 TSP = 600 mg. So that is about 416 doses for $100 or 13.8 months of um Palmitoylethanolamide for $100. Of course you are not getting Luteolen, so you still want that.

Interestingly, Study shows PEA-LUT (palmitoylethanolamide and luteolin) improves smell training outcomes: You can read more about the study here: Effect of Ultra-Micronized Palmitoylethanolamide and Luteolin on Olfaction and Memory in Patients with Long COVID: Results of a Longitudinal Study 2022 ncbi.nlm.nih.gov/pmc/articl...

Hope-full1970 in reply to Bolt_Upright11 days ago

That's great information. Thank you for sharing!

JayPwP in reply to chartist11 days ago

I feel Melatonin is a better option than PEA.

chartist in reply to JayPwP11 days ago

I'm kind of partial to natural healthful things that are native to the body and melatonin meets that criteria. Melatonin also has very significant research supporting its use for many health issues and PD is one of those.

Art

Possmenatt in reply to chartist11 days ago

Also seems handy for chronic pain. For me it also has helped with spinal arthritis and helping with a stiff shoulder 😃. I’m still working in a physical job. Every bit helps 😃

“Palmitoylethanolamide (PEA), a naturally occurring fatty acid amide, has demonstrated utility in the treatment of neuropathic and inflammatory pain. Emerging reports have supported a possible role for its use in the treatment of chronic pain, although this remains controversial.”

ncbi.nlm.nih.gov/pmc/articl...

Possmenatt12 days ago

I have been using PEA and luteolin with positive effects. I’m intending to continue using it for the moment. Anyone using a umPea-Lut

Pea and luteolin

Hope-full1970 in reply to Possmenatt12 days ago

Thanks!!

Gigiopollo in reply to Possmenatt11 days ago

How many capsules do you take per day? And how many mg does each capsule contain? Thanks!

Possmenatt in reply to Gigiopollo11 days ago

I’m taking 2 a day in the afternoon. Just ordered more and still in the evaluation stage. So far so good 😃

Pea and luteolin

LAJ12345 in reply to Possmenatt11 days ago

Yes, my husband has been taking it for a while now

JCRO11 days ago

This got me using umPEA two years ago:

mdpi-res.com/d_attachment/b...

Worth the long read. Bolt_Upright identified the supplement first on HU I think a couple of years ago.

Bolt_Upright in reply to JCRO11 days ago

I use the micronized usually, but I also have this and should use it more: USA LAB Tested Bulk Ultra-micronized Palmitoylethanolamide Powder 99% Pure (250 Grams) $100 amazon.com/gp/product/B07NJ...

According to my scale, 1/2 TSP = 600 mg. So that is about 416 doses for $100 or 13.8 months of um Palmitoylethanolamide for $100. Of course you are not getting Luteolen, so you still want that.

Ksemple198111 days ago

I found this post from 2 years ago. I thought it might help.

So I was bouncing around and found this article: Palmitoylethanolamide/Luteolin as Adjuvant Therapy to Improve an Unusual Case of Camptocormia in a Patient with Parkinson’s Disease: A Case Report 2021 ncbi.nlm.nih.gov/labs/pmc/a... This is a single case report about a fairly unusual condition related to PD and did not hold my attention.

But then I stumbled upon: Randomized clinical trial "olfactory dysfunction after COVID-19: olfactory rehabilitation therapy vs. intervention treatment with Palmitoylethanolamide and Luteolin" 2021 pubmed.ncbi.nlm.nih.gov/341... and this showed the combination of Palmitoylethanolamide and Luteolin improved the sense of smell in people who had COVID, and it worked better the longer their sense of smell had been diminished.

So... It treats Camptocormia in a patient with PD AND rehabilitates the olfactory system. Let's search on "Palmitoylethanolamide" + "Parkinson's":

Ultra-micronized Palmitoylethanolamide: An Efficacious Adjuvant Therapy for Parkinson's Disease pubmed.ncbi.nlm.nih.gov/283...

" Background: Parkinson's disease (PD) is the subject of intense efforts to develop strategies that slow down or stop disease progression and disability. Substantial evidence points to a prominent role for neuroinflammation in the underlying dopaminergic cell death. Ultramicronized palmitoylethanolamide (um-PEA) is well-known for its ability to promote the resolution of neuroinflammation and exert neuroprotection. This study was designed to assess the efficacy of um-PEA as adjuvant therapy in patients with advanced PD.

Method: Thirty PD patients receiving levodopa were included in the study. The revised- Movement Disorder Society/Unified Parkinson's Disease Rating Scale (MDS-UPDRS) questionnaire was used to assess motor and non-motor symptoms. Clinical assessments were carried out before and after addition of um-PEA (600 mg). MDS-UPDRS questionnaire total score for parts I, II, III, and IV was analyzed using the Generalized Linear Mixed Model, followed by the Wilcoxon signed-rank test to evaluate the difference of each item's mean score between baseline and end of um-PEA treatment.

Results: Addition of um-PEA to PD patients receiving levodopa therapy elicited a significant and progressive reduction in the total MDS-UPDRS score (parts I, II, III and IV). For each item, the mean score difference between baseline and end of um-PEA treatment showed a significant reduction in most nonmotor and motor symptoms. The number of patients with symptoms at basal was reduced after one year of um-PEA treatment. None of the participants reported side effects attributable to the addition of um-PEA.

Conclusion: um-PEA slowed down disease progression and disability in PD patients, suggesting that um-PEA may be an efficacious adjuvant therapy for PD. "

Seems like kind of a big deal

Bolt_Upright in reply to Ksemple198111 days ago

I use the micronized usually, but I also have this and should use it more: USA LAB Tested Bulk Ultra-micronized Palmitoylethanolamide Powder 99% Pure (250 Grams) $100 amazon.com/gp/product/B07NJ...

According to my scale, 1/2 TSP = 600 mg. So that is about 416 doses for $100 or 13.8 months of um Palmitoylethanolamide for $100. Of course you are not getting Luteolen, so you still want that.