Duloxetine problem

[kaypeeoh]

Dr Mercola says not to use duloxetine. I don't remember why. But after several days without it I seem to be eating a ton of food. Normally I don't eat breakfast. I avoid carbs and sugars. But now Im eating two breakfasts, two lunches, two dinners and a lot of snacks. I'm afraid to get on the bathroom scale, worried that I've gained a lot of weight. Is this normal behavior with duloxetine-deficiency?

[Rufous2]

Do you mean "duloxetine withdrawal?" I don't think there's any such thing as "duloxetine deficiency." 😀

How much were you taking? Did you quit cold turkey? Most psychotropic meds should be tapered slowly, to avoid "discontinuation syndromes."

[Boscoejean]

"According to Cymbalta's prescribing information, people who took the drug actually showed decreased appetite more frequently than people who took a placebo.

healthline.com/health/depre....

[Rufous2 in reply to Boscoejean]

That would comport with what kaypeeoh is experiencing, ie his appetite has increased in the absence of duloxetine.

[Sydney75]

Psyche meds need to be tapered off to prevent withdrawal. It does reduce appetite unlike tricyclic antidepressants which increase appetite. (Some people)

[Bolt_Upright]

Why did you stop taking it?

[kaypeeoh]

Dr Mercola said to.

[Juliegrace in reply to kaypeeoh]

Have you talked to your actual doctor?

[amykp]

Really? If you can't find his reasoning, I wouldn't blindly leap to his conclusion, unless it makes YOU feel better. Mercola has had some good ideas (I used to follow him) but also some questionable ones imo...especially now.

motherjones.com/politics/20...

sheilakealey.com/nutrition-...

...there is lots more

[rleedc in reply to amykp]

I agree, Dr. Mercola does have some questionable ideas.

[Rufous2]

I can certainly understand wanting to get off of a medication if you're not sure it's doing any good, but please consider tapering.

[LAJ12345]

When I tapered my hubby off sertraline and mirtazapine I decreased it by about 10% every few weeks. I weighed it on a jewellers scale. (10% of the remains dose rather than original dose) so it took about 6 months. I had the last 10%-compounded to make it into a capsule of powder and carried on until at 1%. I did try going straight from 10% to zero but he had withdrawal symptoms.

Those drugs have a long half life so the last 10% is the hardest to get off if you do it too quickly. You have the tail of the previous doses underlying the recent reduced dose so when they peter out it’s like coming off a much larger dose more suddenly.

After the last dose I carried on giving him sugar capsules for 2 more weeks just in case of the placebo effect making him psychologically feel worse. After 2 weeks on sugar pills I told him he had been off them for 2 weeks. He didn’t seem to suffer withdrawal.

He had previously trying cutting back fast as prescribed by the gp but had a big relapse a few months later of depression. Pleased to say that on the improved current diet and exercise regime depression is a thing of the past, but anxiety is still an issue sometimes. For that he takes clonazapam 1 tablet cut into 1/4 spread over the day. This drug is the only thing I think has helped with mental health issues. He doesn’t suffer any symptoms from it at this low dose.

You could try going back to a small amount and taper more slowly.

[MarionP in reply to LAJ12345]

Why don't you take a look at my comment just below, and not just for the momentary conversation but apropos of our just recently previous conversation too since you were asking about "bait and switch." Watch the video to the end.

[LAJ12345 in reply to MarionP]

Was this reply for me?

[MarionP in reply to LAJ12345]

Yes it's just what you were asking about at the very end of the Pepto-Bismol conversation, the process of making something more complicated with error and with someone not knowing that's what happening is called is called "bait and switch." It's also a sales pitch. Doctors in training play the game to challenge each other into being less likely to be fooled by appearances because diseases can mimic each other, and making mistakes that add to the complicated presentation and then the case is turned over to another doctor who now has two mysteries to unravel often in an emergency situation... it's called "bait and switch"... I.e Pepto-Bismol bismuth poisoning mimicking Parkinson's, treat for Parkinson's when none exists, and now you have two problems without much help in figuring out what is going on that was your last comment to me during the Pepto-Bismol strain.. well that film is exactly the same thing so I thought yeah we were just talking about that here's a perfect example of it...well we have been just talking about the very same thing here when that same kind of theme came up yet again, here talking about parkinsonism not being Parkinson's... It is unfortunate that the label in an expert hands causes or allows people to assume parkinsonism is just step 5 and step 6 is pure Parkinson's and it is not. It's an unfortunate use of the term when a untrained person uses it because it encourages them to create error further complicating the picture and putting the patient in even more danger because help from the truth is now further away while their condition worsens...without understanding that they are doing so. And that's a form of "bait and switch." Bismuth poisoning "looks like" many Parkinson's symptoms, qualifying it for being called parkinsonism..."ism" is a very intentional point among clinicians that it looks like something but could definitely be something else. His first doctors thought it was something other than what it was, and weren't able to help him, so they sent him to a psychiatric facility thinking it was a mental illness not poisoning. Since what they could do for him was up no help, that made things worse for him not better. It's trying to resist what some of former colonies that hung on more to their British terminology as "blinkered." The same thing as illustrated in the phrase "to a hammer, all the world is a nail." Car dealers play the game too, advertise a car on sale or cars on sale for a certain price, but when you get to the dealership all those cars are not available but we have something just as nice for $3,000 more and something that has a much better profit profile for us here at the dealership sorry about that. In other words, they flew some "bait" at you, got you interested just like you were a fish biting on bait in a stream, reel you in with it, and when you get in you find your hooked and caught and what you were tempted with was not actually food, it was a hook that had been baited and then they switch you to something else, having known all along that they did not have the offer they were making to you available in the first place. Thus "bait and switch."

[MarionP]

Hey listen: you can't get duloxetine without a prescription. So why aren't you talking to your prescription writer? You are a DVM yourself. WTF are you doing listening to an internet con artist? The very concept must by necessity include the possibility of sociopathy as I think I've mentioned before.

If you have been on duloxetine for many months, or perhaps a year even, and you are going cold turkey, then you're going to have to expect some acute withdrawal symptoms as a possibility. That's why people who are on it for depression or chronic pain management for example are often told they may have to take it for the rest of their life, and the literature is pretty replete with ideas about eventual down regulation of the receptors that respond to duloxetine, meaning you are dependent on duloxetine for something your body normally supplies, because the presence of the duloxetine may have told your body, through a negative feedback loop, to shut down or deactivate those cells that produce what the duloxetine is now supplying... Which for the most part what duloxetine does is inhibits your uptake of adrenaline and noradrenaline, so that you're naturally produced adrenaline and noradrenaline stay in your system longer, doing whatever they do. Antidepressants in general, the ssris anyway, and perhaps duloxetine as well since it is an snri which includes serotonin uptake inhibition, once you have established a dependency, it may take months on up to 6 or 12 months to gradually get yourself weaned off of the duloxetine, and perhaps especially if you're on the 60 mg dose which most people are because really 60 seems to be the most therapeutic dose for most people. While I was still working I knew of at least once psychiatrist who said it's possible it might be necessary to go up to 18 months of gradual withdrawal in some cases. Well that's extreme but he said yeah might have to in a few very sensitive cases. So I guess that, although it's not going to take you as long as some of those extremes, in the meantime you are going through acute withdrawal. If you haven't been on it very long then probably you'll be okay and eventually everything will come back to baseline but how long that will be and what you will have to go through in the meantime I don't really know. You really need to be talking to your doctor STAT, and I don't mean Mercola.

Meanwhile for everybody else, here's a little story I think is a perfect example of why you don't just go unquestioningly listening to some guy on the internet. Click on the below link search term, or copy-paste into your search engine (exactly as I have copied it, don't worry if the sentence isn't quite complete or doesn't seem to finish right) and then navigate to the video that says it is 14:32 long. (14 minutes 32 seconds.)

Okay below is the search term you copy paste into your browser's search engine or search window, and select the video that says it is 14:32 minutes long. Ignore the actual syntax, just copy-pasted the way it is and it will get you where you need to be.

Here it is:

A woman drank 1 Liter Soy Sauce Colon Cleanse in 2 hours. this is Chubbyemu

[kaypeeoh]

Thanks for the note. I had LASIK. It left me unable to drive at night. For a while I hired a driver but ultimately had to give up large animal practice and stick to just small animal practice. Large animal medicine is usually done in the field or barn. Small animal vets work indoors, like real doctors.

While in college I was handed a master's degree study and told to repeat the author's work. But my efforts didn't jibe with the author. So the teacher sided with the author and gave me a "C", the only "C" I had in 9 years of college.

I followed Dr Mercola because he espoused HIIT. I used a treadmill. He told me that could lead to injury. Since I ended up needing Achilles surgery, I guess he was right. I attended a conference where he was one of the speakers.

He talked about how cells phones cause brain cancer.