Hope bioscience is enrolling in 2 clinical trials

[7springshollow]

Participation is free. Location is Sugarland Texas. Check this link for more information. This company is doing some amazing work.hope.bio/amp/two-clinical-t...

[jeffreyn]

The (old) news release that you linked to does mention two trials, but one of them has already completed. The completed trial (N=24) used autologous (i.e. patient's own) adipose tissue (i.e. fat) mesenchymal stem cells.

clinicaltrials.gov/ct2/show...

The trial that is still recruiting (N=60) is using allogeneic (i.e. donor-derived) adipose tissue MSCs.

clinicaltrials.gov/ct2/show...

[7springshollow in reply to jeffreyn]

There are 2 trials recruiting. Both are using donor cells. One is for patients 76 and older. The other is for a younger group. Yes the 24 patient trial wrapped up last month. We are waiting for the results.

[jeffreyn in reply to 7springshollow]

Okay, thanks. Are you able to provide links to the corresponding trial records?

[7springshollow in reply to jeffreyn]

I'm not sure what you are asking for. If you want information on the current trials I can find that. The results for the completed trials using the patients stem cells should be out soon.

[jeffreyn in reply to 7springshollow]

It sounds like the trial that is still recruiting (N=60) has been divided into two trials based on age. I would imagine that at some stage the trial record (NCT04995081) will be updated to reflect this change.

[Boscoejean in reply to jeffreyn]

clinical trials at Hope Biosciences

clinicaltrials.gov/ct2/show...

clinicaltrials.gov/ct2/show...

[jeffreyn in reply to Boscoejean]

Your second link goes to NCT04772378, which is a trial using autologous (i.e. patient's own) cells. I was questioning 7springshollow because she said that two trials were recruiting and that both were using allogeneic (i.e. donated) cells.

[7springshollow in reply to jeffreyn]

I posted an incorrect link. As I said above the 2 trials now enrolling use donor cells.

[Boscoejean in reply to jeffreyn]

my mistake, I was just trying to show the 2 active clinical trials

[Hidden]

in progress....

pd

[Cagey84]

Hi - do you have a connection to Hope Biosciences?

[7springshollow in reply to Cagey84]

No other than I am in a trial and think they are doing great work.

[HugoRipanykhazov]

Is there a different purpose here, between administering this mesenchymal cell treatment intravenously as opposed to by direct injection of the stem cells into the brain?

[7springshollow in reply to HugoRipanykhazov]

There are way less health risks by administering through IV vs injecting into the brain. Hopes belief is the best way to fight this type of disease that has taken years to reach it's current state, is through repeated administration of high doses of stem cells which allows you to eventually get ahead of the disease.

[HugoRipanykhazov]

Within the context of my question, i didn't really understand your answer?

[jeffreyn in reply to HugoRipanykhazov]

Yes, there is a different purpose here, reflected in the different mode of action.

From the Hope Biosciences website:

"The mechanism of action for mesenchymal stem cells have been found to include tissue repair, activation suppression of T and B lymphocytes, release of anti-inflammatory, anti-apoptotic molecules, and changes to the differentiation, maturation, and function of dendritic cells, all of which may aid in correcting immune system dysfunction that plays an important role in the development of Parkinson's disease."

The mechanism of action of IPSC (and ESC) derived dopamine neurons is via the direct replacement of dopamine neurons lost from the substantia nigra.

IPSC: induced pluripotent stem cell

ESC: embryonic stem cell