"Finally, the Broccoli & Sulforaphane Research Group is now operational and has more than 50 members (September 2022). It brings together People with Parkinson’s interested in pursuing their own research on sulforaphane with the aim of slowing the progression of Parkinson’s disease."
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Written by
PDWarrior1900
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Thanks Bolt, To give the Parkinson's community some background, the basic research for this project was done before 2010, by some of the world's best researchers, Prof Albena Dinkova-Kostova in Dundee University, Scotland and Prof Antonio Cuadrado in Madrid.
Prof Dinkova-Kostova is the world's leading scientist on the transcription factor Nrf2, a protein that regulates the action of about about 300 genes in cells and astrocytes responsible for managing oxidative stress, inflammation and mitochondrial function. She also published many articles showing exactly how and where sulforaphane interacts with the another protein, Keap1, which is the negative regulator of Nrf2.
Prof Cuadrado did the most detailed pre-clinical research on sulforaphane to slow the progression of Parkinson's disease. In 2010 he put together a major phase 2 clinical trial on sulforaphane for Parkinson's disease supported by 15 European hospitals. The trial was not funded and the reason given (by MJFF) was that "In the event that sulforaphane would show efficacy in treating Parkinson's disease, no company would be willing to fund the enormous cost of a phase 3 trial for a plant-based molecule that could not be patented " . After this Cuadrado abandoned this line of research. I worked with both Dinkova-Kostova and Cuadrado and picked up from there.
MJFF actually funded the same project earlier in the process. There is almost certainly more to the reasoning behind a refusal to fund further trials than has been stated in this thread.
You're right kevowpd, MJFF funded Cuadrado's preclinical research and when he got good results refused to fund the phase 2. More information in patientresearcher.com/2022/...
You got it PDWarrior, but it's worse than that. There is money being made from PD, in dopamine replacement therapy. But you mustn't touch the upstream stages of the disease which would weaken demand for dopamine replacement therapy. Sulforaphane does just that.
I look at it a bit differently: There is no profit in Sulforaphane, which is fine by me as I know where to get sulforaphane. Just finished my 2 cups of sprouts and hamburger and onions breakfast. Tastes great every day.
Hey! That's not fair talking about 'delicious food'! (LOL) I'm on day #272 of O.M.A.D. (one meal a day with my calories eaten within a 2 hour window -- fasting 22 hours to heal my gut)
WOW! Thanks for the info. As I always say, the people who understand PD, and the difficulty that it presents to it’s sufferers, are the people who have, unfortunately, been diagnosed with PD, a neurodegenerative disease, that none of us ever wanted! You contribute lots of info. to this forum, PDwarrior1900, and I value, and appreciate your contribution! ddm
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