Propanolol Tolerance

[scotta]

I have mixed tremor (PD plus ET). For my tremor, I find that CD/LD plus propanolol works really well to manage my tremor symptoms. At least that was true until last week when I suddenly stopped getting any effect from the propanolol. No reduction in tremor and no lowering of BP as I have come to expect. Researching this, I found that about 10% of propanolol users develop a tolerance to the drug after about a year of daily use and this seems like the most likely explanation. I've heard that Nadolol is another beta-blocker that can work well for PD.

Here's my question: If I developed a tolerance for propanolol, will that tolerance still occur if I switch to another beta-blocker like nadolol or are they different enough that tolerance to these two drugs are developed independently? I would like to use one of the beta-blockers until I build up a tolerance and then switch to the other until I develop a tolerance to the other, and so on. I'm trying to avoid taking a break from taking beta-blockers to make the propanolol effective again.